Results 61 to 70 of about 69,782 (261)

Anti‐PD‐1 Nanobody‐Armored MSLN CAR‐T Therapy for Malignant Mesothelioma: Preclinical and Clinical Studies

Advanced Science, EarlyView.
A novel therapy using engineered immune cells (NAC‐T cells) showed promise for refractory malignant mesothelioma. Based on the encouraging preclinical data, the first‐in‐human trial is initiated, demonstrating tolerable safety and promising anti‐tumor activity (ORR 63.6%, DCR 100%, including one CR).
Yan Sun, Haochen Yang, Qing Xu, Xingya Li, Jinxing Lou, Jianchun Duan, Jiachen Xu, Zhuqing Liu, Yong Xia, Zhicai Lin, Linlin Li, Dan Sun, Jiaguo Li, Tao Liu, Jun Guo, Wenfeng Xu, Weimin Zhu, Yi Liu, Boyang Sun, Jia Zhong, Lijie Rong, Qijun Qian, Chenqi Xu, Jie Wang   +23 more
wiley   +1 more source

Switching off malignant mesothelioma : exploiting the hypoxic microenvironment [PDF]

, 2017
Malignant mesotheliomas are aggressive, asbestos-related cancers with poor patient prognosis, typically arising in the mesothelial surfaces of tissues in pleural and peritoneal cavity.
Bennewith, KL, Churg, A, Collins, CC, Mutti, L, Nabavi, N, Wang, Y   +5 more
core   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

The influence of the diagnostic technique on the histopathological diagnosis in malignant mesothelioma [PDF]

, 1991
In the histopathology of malignant mesotheliomas three different types (epithelial, connective tissue and mixed type) are distinguished. Some authors believe all tumours to be of mixed type, but consider that due to inadequate sampling or small biopsies ...
Gelder, T. (Teun) van, Hoogsteden, H.C. (Henk), Kwast, Th.H. (Theo) van der, Planteydt, H.T. (Hans), Vandenbroucke, J.P. (Jan)   +4 more
core   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Malignant Pleural Mesothelioma [PDF]

Mayo Clinic Proceedings, 2016
Melanie C, Bois, Hee Eun, Lee, Lori A, Erickson   +2 more
  +7 more sources

ECM Mechanoregulation in Malignant Pleural Mesothelioma

Frontiers in Bioengineering and Biotechnology, 2022
Malignant pleural mesothelioma is a relatively rare, but devastating tumor, because of the difficulties in providing early diagnosis and effective treatments with conventional chemo- and radiotherapies. Patients usually present pleural effusions that can
Valeria Panzetta, Valeria Panzetta, Valeria Panzetta, Ida Musella, Ida Musella, Sabato Fusco, Paolo A. Netti, Paolo A. Netti, Paolo A. Netti   +8 more
doaj   +1 more source

Twenty‐Year Longitudinal Cohort Study of Cancer Incidence and Mortality Among Workers in Two Primary Aluminum Prebake Smelters

American Journal of Industrial Medicine, EarlyView.
ABSTRACT Background Classified as carcinogenic to humans by the International Agency for Research on Cancer, aluminum production has been transitioning towards lower polycyclic aromatic hydrocarbon‐emitting prebake smelters. This study explored the risk of cancer and mortality over 20 years follow‐up among a cohort of aluminum prebake smelter workers ...
Natasha Kinsman, Christina Dimitriadis, Anthony Del Monaco, Geza Benke, Sophia Xie, Malcolm Sim, StellaMay Gwini, Karen Walker‐Bone   +7 more
wiley   +1 more source

Pleural Malignancy – A Rare Presentation

Medical Journal of Dr. D.Y. Patil Vidyapeeth
Malignant mesothelioma is a cancerous proliferation of mesothelial cells that affects a significant portion of the pleural cavity. Asbestos exposure is a known risk factor for the development of malignant mesothelioma.
Sachinkumar Soma Dole, M. S. Barthwal
doaj   +1 more source

Commentary on Notification and Recordkeeping of Occupational Mesothelioma in India

American Journal of Industrial Medicine, EarlyView.
ABSTRACT In India, some occupational diseases are notifiable under the Mines Act, 1952, and the Factories Act, 1948. Mesothelioma, primarily attributable to asbestos exposure, has been listed specifically as one of the notifiable diseases under the Mines Act, 1952, and is notifiable under the category of occupational cancer in the Factories Act, 1948 ...
Raja Singh, Arthur L. Frank
wiley   +1 more source