Results 41 to 50 of about 432,885 (215)

Mesothelioma in South Africa 3 decades post peak of asbestos production an analysis of a claims database of asbestos ex-miners [PDF]

, 2012
Includes bibliographical references.The peak in production of the three forms of asbestos that were commercially mined in South Africa occurred in the years between 1970 and 1977.
Mothemela, Mokgadi
core   +1 more source

Arrhythmias associated with immune checkpoint inhibitor therapy—A clinical perspective

British Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitors (ICIs) have transformed cancer therapy but are associated with a growing spectrum of cardiovascular immune‐related adverse events. Among these, arrhythmias represent a rare yet potentially life‐threatening complication. ICI‐induced arrhythmias encompass a wide clinical spectrum, including atrial arrhythmias, conduction ...
Dong Wang, Melanie Ricke‐Hoch, David Duncker, Johann Bauersachs, Dominik Berliner   +4 more
wiley   +1 more source

Lactate and Lactylation: What We Know and What We Expect in Tumour Progression

Cell Proliferation, EarlyView.
Lactate and lactylation in cancer cells have been shown to accelerate tumour development in various ways, including stemness generation, metabolic dysregulation, cell death, chemotherapy resistance, and cell cycle disorder. In addition, lactate and lactylation promote angiogenesis and create an immunosuppressive microenvironment, which promotes tumour ...
Qi Zhang, Zhenzhen Han, Youjia Duan
wiley   +1 more source

The usefulness of full-thickness biopsy during semi-rigid pleuroscopy for differentiating between malignant pleural mesothelioma and non-specific pleurisy

BMC Pulmonary Medicine
Background Malignant pleural mesothelioma is a rare disease with a poor prognosis; distinguishing it from non-specific pleurisy is essential for determining an appropriate treatment strategy. We aimed to evaluate the diagnostic utility and safety of full-
Takahiro Ueda, Toshiyuki Nakai, Sayaka Tanaka, Hiroaki Nagamine, Atsushi Miyamoto, Misako Nishimura, Yoshiya Matsumoto, Kanako Sato, Kazuhiro Yamada, Tetsuya Watanabe, Kazuhisa Asai, Yuji Matsumoto, Yu Mikami, Tomoya Kawaguchi   +13 more
doaj   +1 more source

ECM Mechanoregulation in Malignant Pleural Mesothelioma

Frontiers in Bioengineering and Biotechnology, 2022
Malignant pleural mesothelioma is a relatively rare, but devastating tumor, because of the difficulties in providing early diagnosis and effective treatments with conventional chemo- and radiotherapies. Patients usually present pleural effusions that can
Valeria Panzetta, Valeria Panzetta, Valeria Panzetta, Ida Musella, Ida Musella, Sabato Fusco, Paolo A. Netti, Paolo A. Netti, Paolo A. Netti   +8 more
doaj   +1 more source

Clinical Outcomes of Gradual Corticosteroid Tapering for Immune Checkpoint Inhibitor‐Induced Liver Injury

Hepatology Research, EarlyView.
Patients with severe ICI‐induced liver injury are commonly treated with corticosteroids, but the optimal tapering strategy remains uncertain. In this study, a gradual corticosteroid tapering strategy based partly on Japanese clinical practice for autoimmune hepatitis was associated with a low rate of relapse and enabled many patients to safely resume ...
Naoto Soma, Yoshihito Uchida, Kayoko Sugawara, Masamitsu Nakao, Nobuaki Nakayama, Yukinori Imai, Suguru Mizuno, Satoshi Mochida   +7 more
wiley   +1 more source

Surgery in Malignant Pleural Mesothelioma

Journal of Thoracic Oncology, 2018
Surgical intervention plays an important role in the diagnosis, staging, and treatment of malignant pleural mesothelioma (MPM) and can be applied with curative or palliative intent. The overall aim of surgery should be, as in any oncologic surgery, the macroscopic complete resection (MCR) of the tumor.
Bueno, Raphael, Opitz, Isabelle
openaire   +4 more sources

Heterogeneity in Malignant Pleural Mesothelioma [PDF]

International Journal of Molecular Sciences, 2018
Despite advances in malignant pleural mesothelioma therapy, life expectancy of affected patients remains short. The limited efficiency of treatment options is mainly caused by inter- and intra-tumor heterogeneity of mesotheliomas. This diversity can be observed at the morphological and molecular levels. Molecular analyses reveal a high heterogeneity (i)
Oehl, Kathrin, Vrugt, Bart, Opitz, Isabelle, Meerang, Mayura   +3 more
openaire   +4 more sources

Pleural Malignancy – A Rare Presentation

Medical Journal of Dr. D.Y. Patil Vidyapeeth
Malignant mesothelioma is a cancerous proliferation of mesothelial cells that affects a significant portion of the pleural cavity. Asbestos exposure is a known risk factor for the development of malignant mesothelioma.
Sachinkumar Soma Dole, M. S. Barthwal
doaj   +1 more source

Poorly differentiated lung adenocarcinomas with concurrent ALK and CD30 expression: a diagnostic pitfall mimicking ALK‐positive anaplastic large‐cell lymphoma

Histopathology, Volume 89, Issue 6, Page 1031-1041, December 2026.
Poorly differentiated lung adenocarcinomas with concurrent anaplastic lymphoma kinase (ALK) and CD30 expression closely mimic ALK‐positive anaplastic large‐cell lymphoma, creating a significant diagnostic pitfall. Accurate classification requires comprehensive integration of clinical, radiologic, morphologic, immunophenotypic and molecular findings ...
Jietian Jin, Wenjian Cen, Qin Yan, Yangshan Chen, Chaoyun Huang, Yanfeng Feng, Neng Jiang   +6 more
wiley   +1 more source