Results 31 to 40 of about 432,885 (215)

Regulatory harmonization: Evolution, globalization and future directions

British Journal of Clinical Pharmacology, EarlyView.
Regulatory harmonization has become an increasingly important and accepted approach to streamline regulatory review processes and expedite access to safe, effective and high‐quality medicines globally. This review explores the evolution and current status of regulatory harmonization, convergence and reliance initiatives.
Orin Chisholm, Elaine Y. L. Blair, Christine Y. Lu   +2 more
wiley   +1 more source

Hypervision Proton Surgery: The Future Direction of Proton Therapy

iNew Medicine, EarlyView.
ABSTRACT Proton beams provide unique physical advantages characterized by a low entrance dose, negligible exit dose, and a sharp Bragg peak, which enable superior sparing of normal tissues and support safe dose escalation for improved tumor control. However, conventional photon‐based fractionation remains widely used in proton therapy, where prolonged ...
Li Li, Shuanghu Yuan
wiley   +1 more source

Epidemiology, diagnosis and treatment of the malignant pleural mesothelioma, a narrative review of literature. [PDF]

, 2021
The malignant pleural mesothelioma is a very aggressive tumor which is arising from mesothelial cells and is associated with asbestos exposure. It is a heterogeneous cancer that shows a complex pattern of molecular changes, including genetic, chromosomic,
Schumann, Sven Oliver, Kocher, Gregor, Minervini, Fabrizio, Fabrizio Minervini, Sven Oliver Schumann, Gregor Kocher   +5 more
core   +2 more sources

Value of plasma and pleural effusion fibulin-3 levels in the diagnosis of malignant pleural mesothelioma effusions

Egyptian Journal of Chest Disease and Tuberculosis, 2014
Background: Malignant pleural mesothelioma (MPM) is a highly aggressive tumor that arises from the surface cells of the pleura with a poor survival rate.
Alaa eldin M. Elgazzar, Sameh Embarak, Ali M. Refat, Ahmed Bakry, Ahmed Mokhtar   +4 more
doaj   +1 more source

Safety and Efficacy of Direct Cryobiopsy Specimen Retrieval Through the 3.0‐mm Working Channel of a Therapeutic Bronchoscope Using a 1.1‐mm Cryoprobe: A Multicentre Prospective Observational Study

Respirology, EarlyView.
Safety and efficacy of direct 1.1‐mm cryobiopsy specimen retrieval through a 3.0‐mm therapeutic bronchoscope channel were evaluated. The technique achieved 87.5% overall diagnostic yield, produced specimens three times larger than forceps biopsy, and caused Grade 3 bleeding in only 2.1%.
Yuki Takigawa, Masahide Oki, Ken Sato, Suzuka Matsuoka, Atsushi Torii, Jun Nishimura, Yuka Shinohara, Hiromi Watanabe, Masahiro Sano, Kenichiro Kudo, Akiko Sato, Yoshihito Kogure, Keiichi Fujiwara, Takuo Shibayama   +13 more
wiley   +1 more source

Radiotherapy for malignant pleural mesothelioma

Cochrane Database of Systematic Reviews, 2006
Malignant pleural mesothelioma is a relatively uncommon disease, but the incidence is increasing and is expected to peak in many developed countries in the next two decades. The management of patients with malignant mesothelioma is controversial. Very few patients are suitable for any potentially curative treatment and the effectiveness of radical ...
E, Chapman, E G, Berenstein, M, Diéguez, Z, Ortiz   +3 more
openaire   +3 more sources

Risk factors, prognostic factors, and nomograms for distant metastasis in patients with malignant pleural mesothelioma: A population-based retrospective study

Journal of International Medical Research
Objectives Malignant pleural mesothelioma is a rare and aggressive thoracic tumor with a poor prognosis, wherein distant metastasis is associated with the lowest survival rates.
Quzhe Lu, Chao Liu, Meixiang Xu, Zhi Hu, Hui Yin, Jie Yang   +5 more
doaj   +1 more source

Unusual Cause of Diffuse Pleural Thickening (Malignant Pleural Mesothelioma Mimic): Undifferentiated Epithelioid Malignant Neoplasm

Oman Medical Journal
The symptoms of malignant pleural mesothelioma can be mimicked by some other malignancies, clinically and radiologically. We describe a case of a 57-year-old man whose clinical and radiological findings were consistent with malignant pleural mesothelioma;
Jamal Al-Aghbari, Amira Al Badi, Radiya Al Ajmi, Saif Al Mubaihsi   +3 more
doaj   +1 more source

LINC00892 inhibits hepatocellular carcinoma progression through SBDS/EIF6‐mediated ribosomal stress and interacting with the immune microenvironment

VIEW, EarlyView.
LINC00892 is lowly expressed in HCC. LINC00892 overexpression induces ribosomal stress via inhibiting SBDS, restrains EIF6 nuclear translocation and activates p53 pathway. LINC00892 overexpression and p53 activation jointly suppress HCC progression. High LINC00892 is associted with infiltration of CD8+ T cells, B cells and macrophages, and associated ...
Xu Zhang, Lina Ma, Juan Ma, Long Hai, Lina Wu, Xueyan Feng, Xiangchun Ding   +6 more
wiley   +1 more source

CD93—An emerging vascular target in cancer therapy

British Journal of Pharmacology, EarlyView.
Abstract CD93 is a single‐pass transmembrane glycoprotein that belongs to the C‐type lectin domain group XIV family of proteins. Although it is known to be expressed in other cell types, namely, in some subsets of immune cells, CD93 is primarily expressed on endothelial cells, where it acts as a crucial regulator of angiogenesis.
Beatriz de Alves Pereira, Stefano Barbera, Roberta Lugano, Anna Dimberg   +3 more
wiley   +1 more source