Results 111 to 120 of about 2,304,945 (294)

Malignant Transformation of Oral Lichen Planus

, 2009
Lichen planus is a chronic, immunological mucocutaneous disease with a wide range of clinical manifestations. Since oral lichen planus is considered a pre-malignant condition, a recall system has been recommended one to four times annually to facilitate ...
D Mihailović, L Kesić, R Obradović, G Radičević   +3 more
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The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Timing of Malignant Transformation in Recurrent Versus Nonrecurrent Oral Potentially Malignant Disorders: A Retrospective Study

Objective Postoperative recurrence of oral potentially malignant disorders (OPMDs) is common. This study investigated whether the timing of malignant transformation differs between recurrent and nonrecurrent lesions.
Yun‐Shien Lee, Shih‐Wei Yang, Yi‐Chan Lee   +2 more
core   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

Malignant transformation of a vestibular schwannoma after gamma knife radiosurgery.

, 2013
OBJECTIVE: To report a single case of malignant transformation of a vestibular schwannoma after radiosurgery and review the growing body of literature describing patients with malignant transformation of primary benign tumors after radiosurgery ...
Williamson, Richard W, Eschbacher, Jennifer M, Yanamadala, Vijay, Weisskopf, Peter, Porter, Randall W, Fusco, David J   +5 more
core   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Genomic diversity of HPV6 and HPV11 in recurrent respiratory papillomatosis: Association with malignant transformation in the lungs and clinical outcomes

Tumour Virus Research
Recurrent respiratory papillomatosis (RRP) is a rare, proliferative disease caused by human papillomavirus 6 (HPV6) and HPV11. RRP can occasionally spread and undergo malignant transformation.We analysed samples across time for five RRP patients with ...
Massilva Rahmoun, Audrey Aussel, Sarah Bouzidi, Vincent Pedergnana, Victor Malassigné, Julien Puech, David Veyer, Hélène Péré, Charles Lepine, Fabian Blanc, Nathalie Boulle, Valérie Costes-Martineau, Ignacio G. Bravo   +12 more
doaj   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Pilomatrix Carcinoma Arising From a Previously Excised Giant Pilomatrixoma: A Case Report

Case Reports in Orthopedics
A 49-year-old male presented with a giant pilomatrixoma in the arm that underwent malignant transformation into pilomatrix carcinoma. The patient originally presented with a malaise and back pain.
Robert Wood, Gary Ulrich, Nicholas Tedesco   +2 more
doaj   +1 more source

Technologies for African Agriculture Transformation (TAAT) promotes trailblazing hybrid rice technology adapted to African conditions: TAAT news Vol. 3

, 2023
The African Development Bank launched the Technologies for African Agriculture Transformation (TAAT) programme as part of the Bank’s Feed Africa strategy that is harnessing elite scientific research/technologies and disseminating at scale to African ...
Technologies for African Agricultural Transformation
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