Results 141 to 150 of about 5,196,368 (357)
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
Targeting metabolic mechanisms to overcome temozolomide resistance in glioblastoma
Discover OncologyTemozolomide (TMZ) resistance remains a major clinical obstacle in the treatment of glioblastoma (GBM), a highly aggressive brain tumor with poor prognosis.
Chengrui Yan +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
eQTL and multi-omics integration reveal PPIH as a prognostic and immunotherapeutic biomarker
Frontiers in ImmunologyBackgroundMalignant tumors remain a major threat to global human health. This study aimed to systematically integrate multi-omics data to identify a candidate gene with biomarker potential across diverse cancer types and to evaluate its possible clinical
Fenglin Lv +10 more
doaj +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Glycolysis-related genes for bladder cancer: A Mendelian randomization analysis
Biochemistry and Biophysics ReportsBackground: Glycolysis contributes to tumor progression and treatment resistance in bladder cancer (BLCA). This study aims to identify glycolysis-related genes associated with BLCA risk. Methods: We employed Mendelian randomization (MR) and summary-based
Xuwei Hong +7 more
doaj +1 more source
Imaging biochemistry: applications to breast cancer. [PDF]
, 2001 The use of magnetic resonance spectroscopy (MRS) to investigate breast tumour biochemistry in vivo is reviewed. To this end, results obtained both from patients in vivo and from tumour extracts and model systems are discussed.
Leach, MO, Ronen, SM
core +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Frontiers in Public HealthBackgroundPelvic organ prolapse (POP) is a prevalent condition affecting millions of women globally. Understanding its temporal trends and regional disparities is essential for effective public health interventions.MethodsA cross-sectional analysis was ...
Rui Wang +4 more
doaj +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source