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SMAD4 Palmitoylation Drives a Metabolic‐Transcriptional Circuit to Promote Tumorigenesis and Confers Radiosensitivity in Pancreatic Cancer

open access: yesAdvanced Science, EarlyView.
This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang   +16 more
wiley   +1 more source
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Malignant Brenner Tumor

Archives of Surgery, 1957
The malignant Brenner tumor is an unusually rare lesion, and thus far only six cases have been reported in the literature. Forty-two cases of Brenner tumor were reported from the Mayo Clinic in 1950, all of which were benign. 1 However, a malignant Brenner tumor was seen in 1954. A report of this case is presented herewith.
N, MACKINNON, M B, DOCKERTY
openaire   +2 more sources

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