Results 21 to 30 of about 48,393 (330)
Journal of Pharmacological Sciences, 2021 Hydroxyl radical (•OH) production in the rat striatum during carbon monoxide (CO) poisoning, which inhibits complex IV, was enhanced synergistically by malonate, a mitochondrial complex II inhibitor, but not N-methyl-4-phenylpyridinium or NaCN, complex I
Fumi Kuriiwa +3 more
doaj +1 more source
Preparation of mono-substituted malonic acid half oxyesters (SMAHOs)
Beilstein Journal of Organic Chemistry, 2021 The use of mono-substituted malonic acid half oxyesters (SMAHOs) has been hampered by the sporadic references describing their preparation. An evaluation of different approaches has been achieved, allowing to define the best strategies to introduce ...
Tania Xavier +4 more
doaj +1 more source
Cardiovascular Drugs and Therapy, 2020 Purpose Mitochondrial reactive oxygen species (ROS) production upon reperfusion of ischemic tissue initiates the ischemia/reperfusion (I/R) injury associated with heart attack.
H. Prag +17 more
semanticscholar +1 more source
Pathogens, 2022 There is an urgent need to find novel treatments for combating multidrug-resistant bacteria. Multidrug efflux pumps that expel antibiotics out of cells are major contributors to this problem.
Allea Cauilan, Cristian Ruiz
doaj +1 more source
Uncoupling Protein 3 Catalyzes the Exchange of C4 Metabolites Similar to UCP2
Biomolecules, 2023 Uncoupling protein 3 (UCP3) belongs to the mitochondrial carrier protein superfamily SLC25 and is abundant in brown adipose tissue (BAT), the heart, and muscles.
Jürgen Kreiter +2 more
doaj +1 more source
Probing the Binding Requirements of Modified Nucleosides with the DNA Nuclease SNM1A
Molecules, 2021 SNM1A is a nuclease that is implicated in DNA interstrand crosslink repair and, as such, its inhibition is of interest for overcoming resistance to chemotherapeutic crosslinking agents.
Eva-Maria Dürr, Joanna F. McGouran
doaj +1 more source
Comparative Investigation of Cytotoxic Effects of Structurally Diverse Small Molecules and In Silico Analysis of 1-Acetyl-4-(4-Hydroxyphenyl)piperazine. [PDF]
J Cell Mol MedABSTRACT This study assessed the anticancer activity of boron‐containing and structurally diverse small molecules in 4T1 breast cancer and Caco‐2 colon adenocarcinoma cells. Initial screening showed that five boronic acids lacked significant cytotoxicity, underscoring the structural specificity required for boron‐mediated bioactivity.
Yerlikaya A, Tümer E, Güzel M.
europepmc +2 more sources
A Disjointed Pathway for Malonate Degradation by Rhodopseudomonas palustris
Applied and Environmental Microbiology, 2020 There is interest in understanding how bacteria metabolize malonate because this three-carbon dicarboxylic acid can serve as a building block in bioengineering applications to generate useful compounds that have an odd number of carbons.
Zhaobao Wang +4 more
semanticscholar +1 more source
Synthesis of novel β-aminocyclobutanecarboxylic acid derivatives by a solvent-free aza-Michael addition and subsequent ring closure [PDF]
, 2011 Novel beta-aminocyclobutanecarboxylic acid derivatives were prepared via a sequential solvent-free aza-Michael addition of benzophenone imine across 3-halopropylidenemalonates and base-induced ring closure.
Aitken +44 more
core +1 more source
Acta Crystallographica Section E: Crystallographic Communications, 2018 The title compound, C18H23FO5, was synthesized by reacting diethyl malonate with 1-(4-fluorophenyl)-3-methylbut-2-en-1-one. The molecule adopts a loose conformation stabilized by weak C—H...O and C—H...π interactions.
Sandeep Chandrashekharappa +4 more
doaj +1 more source