Results 51 to 60 of about 35,072 (269)

Biocatalytic Route to Chiral Precursors of β-Substituted-γ-Amino Acids [PDF]

, 2011
In this work, we utilized commercial lipases (from Thermomyces lanuginosa, Rhizopus delemar, and Mucor miehei) as biocatalysts for the efficient synthesis of precursors of β-substituted-γ-amino acids.
Martinez, Carlos A., Mukherjee, Herschel
core   +2 more sources

Chemoenzymatic Route toward a De Novo Enantioselective Total Synthesis of (S)‐Baclofen Based on Metal‐Catalyzed Hydroformylation and Enzymatic Transamination

ChemBioChem, EarlyView.
A unique chemoenzymatic synthesis route toward (S)‐baclofen is presented, which highlights a hydroformylation and biocatalysis step toward the synthesis of such a challenging β‐chiral amino acid. The shown methodology exhibits high conversions and enantiomeric excess and is transferable to other β‐chiral amines and amino acids.
Feodor Belov, Hannah Bork, Luise Hänel, Manideep V. Kollipara, Matthias Höhne, Harald Gröger, Jan von Langermann   +6 more
wiley   +1 more source

Indole Synthesis via Allenyl Ester; Enantioselective Total Synthesis of Geissoschizoline

ChemistryEurope, EarlyView.
An indole synthesis via an allenyl ester intermediate at ambient temperature has been developed. The mild reaction conditions allow the use of a broad range of substrates. Notably, the utility of this approach is demonstrated through the asymmetric total synthesis of geissoschizoline, a Strychnos‐type monoterpenoid indole alkaloid.
Sohsuke Moriue, Honami Nishioka, Yuto Fukuda, Hiromitsu Takayama, Mariko Kitajima, Hayato Ishikawa   +5 more
wiley   +1 more source

Targeting succinate dehydrogenase with malonate ester prodrugs decreases renal ischemia reperfusion injury

Redox Biology, 2020
Renal ischemia reperfusion (IR) injury leads to significant patient morbidity and mortality, and its amelioration is an urgent unmet clinical need.
Timothy E. Beach, Hiran A. Prag, Laura Pala, Angela Logan, Margaret M. Huang, Anja V. Gruszczyk, Jack L. Martin, Krishnaa Mahbubani, Mazin O. Hamed, Sarah A. Hosgood, Michael L. Nicholson, Andrew M. James, Richard C. Hartley, Michael P. Murphy, Kourosh Saeb-Parsy   +14 more
doaj  

Bis(1-pyrenylmethyl)-2-benzyl-2-methyl-malonate as a Cu2+ Ion-Selective Fluoroionophore

Molecules, 2017
A new malonate possessing two pyrene moieties was synthesized as a fluoroionophore, and its structure and fluorescence spectroscopic properties were investigated.
Takayo Moriuchi-Kawakami, Youji Hisada, Akihisa Higashikado, Tsubasa Inoue, Keiichi Fujimori, Toshiyuki Moriuchi   +5 more
doaj   +1 more source

Impact of Oxygen and Sulfur Heteroatom Core Substitution on Catalyst Properties of Phenoxazines and Their Performance in Organocatalyzed Atom Transfer Radical Polymerization (O‐ATRP)

Chemistry – A European Journal, EarlyView.
Phenoxazine core structural modification reveals the impact of charge transfer on stronger excited state reduction potentials. We observed that modifying the core of a photocatalyst that does not exhibit charge transfer yields a highly reducing singlet excited state reduction potential compared to a charge transfer equivalent. Abstract Phenoxazines are
Jessica L. Lathrop, Brandon S. Portela, Robert S. Paton, Garret M. Miyake   +3 more
wiley   +1 more source

Poly[di-μ-aqua-diaqua-di-μ6-malonato-cobalt(II)dipotassium(I)]

Acta Crystallographica Section E, 2011
In the title complex, [CoK2(C3H2O4)2(H2O)4]n, the Co atom is located on a position with site symmetry 2/m, the K atom and one water molecule are located on a mirror plane, and the malonate and one water molecule are located on a twofold rotation axis ...
Adama Sy, Aliou Hamady Barry, Mohamed Gaye, Abdou Salam Sall, Ahmed Driss   +4 more
doaj   +1 more source

The degradation of L-lysine in guinea pig liver homogenate: formation of alpha-aminoadipic acid [PDF]

, 1948
A summary of the little that is known of the metabolism of lysine in animals is as follows: it is indispensable in the diet, its α-amino group does not participate in reversible transamination reaction in vivo (2), neither the L nor D form is attacked by
Borsook, Henry, Deasy, Clara L., Haagen-Smit, A. J., Keighley, Geoffrey, Lowy, Peter H.   +4 more
core   +1 more source

Recent Advances in Detergent Chemistry and Handling Support Membrane Protein Analysis Including Lipid Interactions

Chemistry – A European Journal, EarlyView.
Detergent design parameters determine experimental successes in membrane protein research. Recent progresses in detergent chemistry are reviewed to promote the top‐down design of non‐ionic detergents for the purification and analysis of intact membrane proteins, including lipid interactions.
Katharina Alker, Jan‐Simon Behnke, Leonhard H. Urner   +2 more
wiley   +1 more source

Crystal structure of a Pseudomonas malonate decarboxylase holoenzyme hetero-tetramer

Nature Communications, 2017
Some aerobic bacteria contain a biotin-independent malonate decarboxylase (MDC), which allows them to use malonate as the sole carbon source. Here, the authors present the crystal structure of a Pseudomonas MDC and give insights into its catalytic ...
Riyaz Maderbocus, Blanche L. Fields, Keith Hamilton, Shukun Luo, Timothy H. Tran, Lars E. P. Dietrich, Liang Tong   +6 more
doaj   +1 more source