Results 141 to 150 of about 940,824 (353)
Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer
Molecular Oncology, EarlyView.Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte +10 more
wiley +1 more source
Heterochromosomes in mammals [PDF]
Experimental Biology and Medicine, 1912 Heterochromosomes have now been reported for the male germ cells of the following mammals: man and rat (Guyer, '10); armadillo (Newman and Patterson, '10); opossum (Jordan, '11); guinea-pig (Stevens, '11); and bat (Jordan, '12). Winiwarter and Sainmont, '09, report a longitudinally split “monosome” in the oocyte of the cat.A comparative study of ...
openaire +3 more sources
Possible role of human ribonuclease dicer in the regulation of R loops
FEBS Open Bio, EarlyView.R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik +2 more
wiley +1 more source
, 2002 Bajo la forma de preguntas y respuestas trata de despertar la curiosidad sobre las características, el comportamiento, ciclo de vida, y los hábitats de todo tipo de mamíferos, desde las musarañas a los elefantes. Para profundizar en su estudio y el respeto por su conservación. Recomendado para ocho a doce años.
openaire +3 more sources
Cold Spring Harbor Perspectives in Biology, 2014 DNA methylation is one of the best characterized epigenetic modifications. In mammals it is involved in various biological processes including the silencing of transposable elements, regulation of gene expression, genomic imprinting, and X-chromosome ...
E. Li, Yi Zhang
semanticscholar +1 more source
FEBS Open Bio, EarlyView.Etoposide, a topoisomerase II inhibitor, reduces O‐GlcNAcylation in HepG2 liver cancer cells. Further inhibition of O‐GlcNAc transferase by OSMI‐1 enhanced etoposide‐induced apoptosis, lowering the IC50 for viability and increasing the EC50 for cytotoxicity.
Jaehoon Lee +5 more
wiley +1 more source
Lineage-specific transposons drove massive gene expression recruitments during the evolution of pregnancy in mammals [PDF]
arXiv, 2012 A major challenge in biology is explaining how novel characters originate, however, the molecular mechanisms that underlie the emergence of evolutionary innovations are unclear. Here we show that while gene expression in the uterus evolves at a slow and relatively constant rate, it has been punctuated by periods of rapid change associated with the ...
arxiv
AnimalsEncephalitozoon cuniculi and Encephalitozoon hellem are fungus-related, obligate intracellular pathogens belonging to the microsporidia. Both microorganisms occur in mammals, birds and even humans, thus revealing a zoonotic potential.
Katharina Breuninger +2 more
doaj +1 more source