Results 251 to 260 of about 770,892 (320)

Bilirubin Targeting WNK1 to Alleviate NLRP3‐Mediated Neuroinflammation

Advanced Science, EarlyView.
At physiological concentrations, bilirubin binds to the kinase domain of WNK1, thereby augmenting its activity and facilitating the phosphorylation of downstream SPAK/OSR1. This phosphorylation inhibits KCC2 activity, leading to elevate intracellular chloride levels in neurons.
Linfei Mao, Jiayu Lu, Quanjun Yang, Zhenqi Liu, Cuiping Wu, Bingbing Ke, Kaiyan Su, Haolin Yuan, Yaqi Cui, Yao Wang, Richard Salvi, Guang Yang, Shankai Yin, Feng Liu, Chunyan Li   +14 more
wiley   +1 more source

Historical and ongoing inequities shape research visibility in Latin American aquatic mammal paleontology. [PDF]

Commun Biol
Valenzuela-Toro AM, Viglino M, Loch C.
europepmc   +1 more source

GRP78 Nanobody‐Directed Immunotoxin Activates Innate Immunity Through STING Pathway to Synergize Tumor Immunotherapy

Advanced Science, EarlyView.
A GRP78 nanobody‐directed immunotoxin suppresses cancer progression and metastasis by enhancing antitumor immunity via STING pathway activation, offering a pan‐cancer‐targeted approach and immunotherapy combination strategy. Abstract The lack of targetable antigens poses a significant challenge in developing effective cancer‐targeted therapies.
Huifang Wang, Runhua Zhou, Chengchao Xu, Lingyun Dai, Rui Hou, Liuhai Zheng, Chunjin Fu, Guangwei Shi, Jingwei Wang, Yang Li, Jinpeng Cen, Xiaolong Xu, Le Yu, Yilei Li, Jigang Wang, Qingfeng Du, Zhijie Li   +16 more
wiley   +1 more source

Variable Gene Copy Number in Cancer-Related Pathways Is Associated With Cancer Prevalence Across Mammals. [PDF]

Mol Biol Evol
Matthews S, Nikoonejad Fard V, Tollis M, Seoighe C.   +3 more
europepmc   +1 more source

AKT1 Phosphorylates FDX1 to Promote Cuproptosis Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study demonstrates that copper activates the AKT signaling pathway, which inhibits ferredoxin‐1 (FDX1), a key regulator of cuproptosis. AKT1‐mediated FDX1 phosphorylation not only abrogates FDX1‐induced cuproptosis and aerobic respiration but also promotes glycolysis.
Zicheng Sun, Huazhen Xu, Guanming Lu, Ciqiu Yang, Xinya Gao, Jing Zhang, Xin Liu, Yongcheng Chen, Kun Wang, Jianping Guo, Jie Li   +10 more
wiley   +1 more source

Occurrence and genetic diversity of the zoonotic rat hepatitis E virus in small mammal species, Spain. [PDF]

Vet Res
Caballero-Gómez J, Fajardo-Alonso T, Rios-Muñoz L, Cuadrado-Matías R, Somoano A, Panadero R, Casares-Jiménez M, García-Bocanegra I, Ruiz L, Beato-Benítez A, Ruiz-Fons F, Jiménez-Martín D, Espí A, Del Cerro A, Martínez R, Frías M, Rivero-Juárez A, Rivero A.   +17 more
europepmc   +1 more source

Pinoresinol Diglucoside Attenuates Nuclear Receptor Coactivator 4‐Mediated Ferritinophagy Associated with Cisplatin‐Induced Hearing Loss

Advanced Science, EarlyView.
Pinoresinol diglucoside, a bioactive component extracted from traditional Chinese medicine, attenuates cisplatin‐induced ototoxicity in vivo and in vitro. The protective effect is achieved by downregulation of Socs1. The present study is the first to investigate the expression and function of Socs1 in inner ear, which is known to promote ferroptosis ...
Yin Chen, Cheng Cheng, Ao Li, Dengbin Ma, Siyu Li, Handong Wang, Song Gao, Dingding Liu, Panpan Song, Chenjie Yu, Xiaoyun Qian, Guoqiang Wan, Xia Gao   +12 more
wiley   +1 more source

New remarkably complete skeleton of Mixodectes reveals arboreality in a large Paleocene primatomorphan mammal following the Cretaceous-Paleogene mass extinction. [PDF]

Sci Rep
Chester SGB, Williamson TE, Crowell JW, Silcox MT, Bloch JI, Sargis EJ.   +5 more
europepmc   +1 more source

On some Remains of Grypotherium (Neomylodori) listai and associated Mammals from a Cavern near Consuelo Cove, Last Hope Inlet, Patagonia.

, 1900
Arthur Smith Woodward
openalex   +2 more sources

Mop3 Is an Essential Component of the Master Circadian Pacemaker in Mammals

Cell, 2000
M. Bunger, L. Wilsbacher, S. Moran, C. Clendenin, Laurel A. Radcliffe, J. Hogenesch, M. Simon, J. Takahashi, C. Bradfield   +8 more
semanticscholar   +1 more source