Results 31 to 40 of about 516,150 (266)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Drivers of spring migration phenology in Rocky Mountain elk

Scientific Reports
By migrating, ungulates take advantage of cyclical fluctuations in resources, which allows them to persist at greater population numbers than they would in the absence of these seasonal movements.
Storm Crews, Nathaniel D. Rayl, Mathew W. Alldredge, Eric J. Bergman, Charles R. Anderson, Guillaume Bastille-Rousseau   +5 more
doaj   +1 more source

Silent predators: Revealing the parasites of Himalayan musk deer (Moschus leucogaster) in Manaslu Conservation Area, Nepal

International Journal for Parasitology: Parasites and Wildlife
Parasites pose a significant threat to wildlife, yet their impact remains largely understudied, with limited research conducted on the parasites of wild animals.
Bishnu Achhami, Shila Gurung, Sujan Deshar, Sapana Khaiju, Lekha Kumari Thapa, Sabita Gurung   +5 more
doaj   +1 more source

Overview of Current Research on Wolves in Russia

Frontiers in Ecology and Evolution, 2022
This paper provides an overview of wolf research in Russia at the beginning of the 21st century. Wolf research covered various directions, including population density estimation, management methods and minimization of human-wildlife conflicts, general ...
Andrey D. Poyarkov, Miroslav P. Korablev, Eugenia Bragina, Jose Antonio Hernandez-Blanco   +3 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

By-catch of common minke whales (Balaenoptera acutorostrata) in Norwegian demersal trawl and longline fisheries, 2011–2020

NAMMCO Scientific Publications
The Norwegian High Seas Reference Fleet (HSRF) reported one minke whale (Balaenoptera acutorostrata) by-caught in demersal trawl fisheries and one in a longline in the period 2011–2020.
André Moan, Arne Bjørge
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source