Results 81 to 90 of about 142,576 (312)

A model to describe growth patterns of the mammary gland during pregnancy and lactation. [PDF]

, 1997
Extensive proliferation and death of cells in the mammary gland occur during pregnancy and lactation. In this study, a mechanistic model was developed that yielded a single equation to describe the pattern of mammary growth of mammals throughout ...
Dijkstra, J., Hanigan, M. D., France, J., Rook, A. J., Beever, D. E., Maas, J.A., Maas, J. A., Rook, A.J., Beever, D.E., Dhanoa, M.S., Hanigan, M.D., Dhanoa, M. S.   +11 more
core   +1 more source

Decoding the Mechanism of Action of a Parasite TGFβ Antagonist Inspires the Creation of Cell‐Type‐Specific TGFβ Modulators

Advanced Science, EarlyView.
The mammalian TGFβ interacts with ubiquitously expressed TGFBR1 and TGFBR2, and current TGFβ‐targeting agents are non‐cell‐selective. The cooperative interaction of the modular parasite TGFβ antagonist with multiple host (co‐)receptors empowers the design of TGM chimeras and bispecific antibodies that activate or inhibit TGFβ signaling in a cell ...
Maarten van Dinther, Tristin Schwartze, Jiying Zhang, Kun Fan, Gerard van der Zon, Luke Power, Cynthia S. Hinck, Claire Ciancia, Ananya Mukundan, Roman Gonzalez‐Prieto, Peter van Veelen, Rick M. Maizels, Andrew P. Hinck, Peter ten Dijke   +13 more
wiley   +1 more source

The Mammary Gland Microenvironment Directs Progenitor Cell Fate In Vivo

International Journal of Cell Biology, 2011
The mammary gland is a unique organ that continually undergoes postnatal developmental changes. In mice, the mammary gland is formed via signals from terminal end buds, which direct ductal growth and elongation.
Karen M. Bussard, Gilbert H. Smith
doaj   +1 more source

Consumption of Mediterranean versus Western Diet Leads to Distinct Mammary Gland Microbiome Populations

Cell Reports, 2018
Summary: Recent identification of a mammary gland-specific microbiome led to studies investigating bacteria populations in breast cancer. Malignant breast tumors have lower Lactobacillus abundance compared with benign lesions, implicating Lactobacillus ...
Carol A. Shively, Thomas C. Register, Susan E. Appt, Thomas B. Clarkson, Beth Uberseder, Kenysha Y.J. Clear, Adam S. Wilson, Akiko Chiba, Janet A. Tooze, Katherine L. Cook   +9 more
doaj   +1 more source

Pleiotropic Functions of Fibroblast Growth Factor Signaling in Embryonic Mammary Gland Development

, 2013
The mammary gland is an ectodermal appendage and a defining feature of mammals. Consistent with it being a recent evolutionary novelty, many of the molecules essential for the ontogeny and morphogenesis of various vertebrate organs, including those in ...
김은정, 정한성
core   +1 more source

Engineering Oncolytic Virus‐Armed Macrophages for Enhanced Cancer Immunotherapy

Advanced Science, EarlyView.
ZIFOA‐M is engineered by conjugating oncolytic adenovirus‐loaded ZIF‐8 nanoparticles onto macrophage surfaces via bioorthogonal chemistry. Upon tumor infiltration, the platform releases OA to downregulate CD47/CD24 on tumor cells, restoring macrophage phagocytosis.
Jilong Wang, Ning Lu, Zhuo Yan, Luyi Ye, Luyao Bai, Shanshan Yuan, Yuting Zhu, Yiru Xiong, Yongheng Bai, Yaping Chen, Junjie Deng   +10 more
wiley   +1 more source

The normal and malignant mammary gland: a fresh look with ER beta onboard

, 2000
Estrogens are important for the development and function of the normal mammary gland as well as for development of mammary cancer. The frontline therapy for treatment of estrogen receptor (ER alpha) positive breast cancer is antiestrogens.
Saji, S, Warner, M, Gustafsson, JA
core   +1 more source

Use and relevance of a bovine mammary gland explant model to study infection responses in bovine mammary tissue [PDF]

, 2007
Our aim was to develop an explant model to define more precisely the early response of bovine mammary epithelial cells to infection. Therefore we investigated the mRNA expression encoding for some soluble immunological factors in lipopolysaccharide (LPS)-
Meyer, Heinrich H D, Wellnitz, Olga, Bruckmaier, Rupert M, Rabot, Aline   +3 more
core   +1 more source

Lighting up Macrophage Reprogramming Assists Immunosuppressive Niche Modulation in Primary Tumors and Tumor‐Draining Lymph Nodes of Breast Cancer

Advanced Science, EarlyView.
This study develops an intelligent NIR‐II‐responsive nanoplatform to combat immunosuppression in breast cancer. It enables real‐time visualization of macrophage activity via “off‐on” fluorescence while simultaneously reprogramming macrophages through the CSF‐1R and CD47‐SIRPα pathways.
Yingbo Li, Di Chang, Jie Yang, Ying Bai, Min Chen, Daoshuang Li, Zuoyu Xu, Jiaxin Yuan, Xiaoxuan Xu, Zhiqi Zhang, Yize Li, Zixin Chen, Jinbing Xie, Zebin Xiao, Shenghong Ju   +14 more
wiley   +1 more source

Primary Mammary Organoid Model of Lactation and Involution

Frontiers in Cell and Developmental Biology, 2020
Mammary gland development occurs mainly after birth and is composed of three successive stages: puberty, pregnancy and lactation, and involution. These developmental stages are associated with major tissue remodeling, including extensive changes in ...
Jakub Sumbal, Jakub Sumbal, Aurelie Chiche, Elsa Charifou, Zuzana Koledova, Han Li   +5 more
doaj   +1 more source