Results 61 to 70 of about 142,576 (312)

S100 proteins in mammary gland regulation and their role in breast cancer metastasis

Advances in Cancer Biology - Metastasis, 2023
S100 proteins have emerged as key regulators in the mammary gland and have been implicated in breast cancer development and metastasis. This review provides a comprehensive overview of the roles of S100 proteins in mammary gland regulation and their ...
Parul Singh, Syed Azmal Ali
doaj   +1 more source

Alteration of gene expression in mammary gland tissue of dairy cows in response to dietary unsaturated fatty acids

, 2011
The aim of this study was to determine the effects of supplementing unprotected dietary unsaturated fatty acids (UFAs) from different plant oils on gene expression in the mammary gland of grazing dairy cows.
Kruijt, L., Baal, J., van, Mach Casellas, N., Jacobs, A.A.A., Smits, M.A.   +4 more
core   +1 more source

Protocol for Studying Embryonic Mammary Gland Branching Morphogenesis Ex Vivo [PDF]

, 2022
Mammary gland development starts during embryogenesis, and the process continues after birth. During development, the mammary gland undergoes massive morphological and physiological alterations including growth, invasion, and branching morphogenesis ...
Kaczyńska, Beata Katarzyna, Lan, Qiang, Satu-Marja Myllymäki, Ewelina Trela, Mikkola, Marja L., Jyoti Satta, Riitta Lindström, Johanna Englund, Kaczynska, Beata, Myllymäki, Satu-Marja, Lindström, Riitta, Satta, Jyoti Prabha, Mikkola, Marja, Qiang Lan, Englund, Johanna, Satta, Jyoti, Marja L. Mikkola, Beata Kaczyńska, Trela, Ewelina   +18 more
core   +1 more source

Unraveling the Molecular Mechanisms Underlying Spontaneous Multipolar Mitosis Through CIN‐seq

Advanced Science, EarlyView.
Multipolar mitosis, a hallmark of chromosomal instability (CIN), drives tumor heterogeneity but is challenging to study in live cells. Using CIN‐seq, a single‐cell multiomics method, we profiled rare CIN events and identified mechanisms associated with viable multipolar mitosis, including PTEN attenuation, Rho GTPase‐driven cytokinesis failure, and ...
Pin‐Rui Su, Ting‐Chun Chou, Maria Teresa López‐Cascales, Junfeng Huang, Tsai‐Ying Chen, Sjoukje van Wieren, Chan Li, Cecile Beerens, Li You, Jelle Storteboom, Miao‐Ping Chien   +10 more
wiley   +1 more source

Significance of advanced lung cancer inflammation index in differentiating benign and malignant breast diseases

Zhongguo linchuang yanjiu
Objective To explore the clinical value of the advanced lung cancer inflammation index (ALI) in the differential diagnosis of benign and malignant breast diseases.
CHENG Xiaocheng, LIU Xueyan, JIAO Fuzhi, QI Jinfeng, YANG Jing, GONG Xiaojun, LIU Huimin, WEI Li, WEI Yuanyuan
doaj   +1 more source

Amphiregulin: Role in mammary gland development and breast cancer

, 2008
Extensive epithelial cell proliferation underlies the ductal morphogenesis of puberty that generates the mammary tree that will eventually fill the fat pad.
Howlin, Jillian,, Martin, Finian, McBryan, Jean, Napoletano, Silvia, Lund University., Howlin, Jillian   +5 more
core   +1 more source

Heat shock protein-90-alpha, a prolactin-STAT5 target gene identified in breast cancer cells, is involved in apoptosis regulation [PDF]

, 2008
Introduction The prolactin-Janus-kinase-2-signal transducer and activator of transcription-5 (JAK2-STAT5) pathway is essential for the development and functional differentiation of the mammary gland.
Liu, R., Bork, Peer, Shemanko, Carrie S., Shemanko, C., Liu, Ruixuan, Pfitzner, Edith, Schultz, J., Christine T Parusel, Jörg Schultz, Groner, Bernd, Parusel, Christine T., Bork, P., Boecher, N., Perotti, Christian, Christian Perotti, Ruixuan Liu, Carrie S Shemanko, Pfitzner, E., Groner, B., Schultz, Jörg, Bernd Groner, Böcher, Nadine, Nadine Böcher, Perotti, C., Peer Bork, Edith Pfitzner, Parusel, C.   +26 more
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TSPYL5 Promotes Triple‐Negative Breast Cancer Metastasis by Antagonizing USP10‐Mediated PTEN Stabilization to Unleash a ZEB1‐Dependent EMT Program

Advanced Science, EarlyView.
The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi, Ming Yi, Shengyu Xie, Zhaokun Wang, Xinyue Zhang, Yangwei Zhang, Rui Tang, Yuan Yang, Yunqiang Liu   +8 more
wiley   +1 more source

Identification of steroid sulfate transport processes in the human mammary gland [PDF]

, 2003
Circulating hormones and local biotransformation of steroid precursors are both sources of estrogen in human mammary tissue. Estrone-3-sulfate (E(1)S) is an important estrogenic form in premenopausal women, and dehydroepiandrosterone sulfate (DHEAS ...
Pizzagalli, F., Meier, P. J., Varga, Z., Huber, R. D., Folkers, G., St-Pierre, M. V.   +5 more
core   +1 more source

Pharmacologic Modulation of ARID3A with Rimegepant Reactivates Type I Interferon Signaling and Sensitizes Triple‐Negative Breast Cancer to PD‐1 Blockade

Advanced Science, EarlyView.
This study identifies ARID3A as a key immunosuppressive transcription factor in TNBC. Its inhibition activates the type I IFN pathway, boosting CD8+ T cell infiltration and sensitizing tumors to anti‐PD‐1. The FDA‐approved migraine drug Rimegepant targets ARID3A, enhances immunotherapy efficacy in preclinical models, and establishes a druggable axis to
Teng Zhou, Yifei Zhu, Cheng Zeng, Jinlu Han, Huiying Huang, Doudou Li, Mingxi Lin, Yizi Jin, Qin Guo, Yuxin Yan, Xinhui Mao, Yifei Zhou, Jian Zhang   +12 more
wiley   +1 more source