Gross tumor assessment is not a reliable measure of the efficacy of chemo-preventive agents for breast cancer in preclinical mouse models [PDF]
Scientific ReportsDespite success in preclinical animal models, most cancer prevention drugs fail to show efficacy in clinical trials. One potential reason could be that study end points in animal models are not sufficiently robust.
Anjana Bhardwaj +6 more
doaj +2 more sources
Magnetic resonance spectroscopy detects differential lipid composition in mammary glands on low fat, high animal fat versus high fructose diets. [PDF]
PLoS ONE, 2018 The effects of consumption of different diets on the fatty acid composition in the mammary glands of SV40 T-antigen (Tag) transgenic mice, a well-established model of human triple-negative breast cancer, were investigated with magnetic resonance ...
Dianning He +10 more
doaj +5 more sources
Research progress on mechanisms and applications of Chinese herbal pairs in treating hyperplasia of mammary gland [PDF]
Frontiers in PharmacologyHyperplasia of Mammary gland (HMG), a common gynecological disorder with potential malignant transformation risk, has been effectively treated using Traditional Chinese Medicine (TCM) herbal pairs.
Lu Liu +7 more
doaj +2 more sources
The Vietnamese swine as a translational model of invasive ductal carcinoma of the breast [PDF]
Animal Models and Experimental MedicineBackground The Vietnamese swine represents a promising animal model due to its anatomical, physiological, and pathophysiological similarities to humans.
Claudia Elizabeth Vera‐Tizatl +6 more
doaj +2 more sources
Mammary gland 3D cell culture systems in farm animals [PDF]
Veterinary Research, 2021 AbstractIn vivo study of tissue or organ biology in mammals is very complex and progress is slowed by poor accessibility of samples and ethical concerns. Fortunately, however, advances in stem cell identification and culture have made it possible to derive in vitro 3D “tissues” called organoids, these three-dimensional structures partly or fully ...
Finot, Laurence +2 more
openaire +5 more sources
Screening through Temperature and Thermal Pattern Analysis in DMBA - Induced Breast Cancer in Wistar Rats [PDF]
Journal of Biomedical Physics and Engineering, 2021 Background: Based on thermal temperatures around the breast, thermography is considered a promising approache providing information about the condition of the breast without any side effects.
Evy Poerbaningtyas +4 more
doaj +1 more source
IRE1 phosphatase PP2Ce regulates adaptive ER stress response in the postpartum mammary gland. [PDF]
, 2013 We recently reported that the PPM1l gene encodes an endoplasmic reticulum (ER) membrane targeted protein phosphatase (named PP2Ce) with highly specific activity towards Inositol-requiring protein-1 (IRE1) and regulates the functional outcome of ER stress.
Lane, Timothy F +6 more
core +14 more sources
Nutritional Regulation of Mammary Gland Development and Milk Synthesis in Animal Models and Dairy Species [PDF]
Genes, 2021 In mammals, milk is essential for the growth, development, and health. Milk quantity and quality are dependent on mammary development, strongly influenced by nutrition. This review provides an overview of the data on nutritional regulations of mammary development and gene expression involved in milk component synthesis. Mammary development is described
Hue-Beauvais, Cathy +3 more
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Pharmaceuticals that cause mammary gland tumors in animals: findings in women [PDF]
Breast Cancer Research and Treatment, 2008 Risk of breast cancer in women was assessed for eight pharmaceuticals that produce mammary tumors in experimental animals, using nested case-control analyses in two cohorts with prescription records in a comprehensive medical care program. The two cohorts were: (1) earlier cohort: 78,118 female members who received prescriptions in 1969-1973, of whom 2,
Gary D, Friedman +5 more
openaire +2 more sources
Effects of age and parity on mammary gland lesions and progenitor cells in the FVB/N-RC mice. [PDF]
PLoS ONE, 2012 The FVB/N mouse strain is extensively used in the development of animal models for breast cancer research. Recently it has been reported that the aging FVB/N mice develop spontaneous mammary lesions and tumors accompanied with abnormalities in the ...
Ahmed Raafat +8 more
doaj +1 more source