Results 191 to 200 of about 55,565 (283)

Targeting Sphingosine‐1‐Phosphate Signaling Attenuates Doxorubicin‐Aggravated Bone Loss in Obese Breast Cancer Mice

Smart Medicine, Volume 5, Issue 2, April 2026.
During obese breast cancer‐bearing mice undergoing chemotherapy, DOX increases the concentration of S1P produced by breast cancer cells, which induces osteoclastogenesis through the activation of the S1PR1/p‐STAT3/NFATc‐1 pathway, thereby exacerbating bone loss in the breast cancer‐bearing mice with high‐fat dietary.
Yu Zhang, Hao Shen, Junjie Niu, Yingkang Huang, Can Zhu, Yi Wang, Yida Chen, Xinyi Cheng, Huilin Yang, Xianrong Zhang, Hao Chen, Hongbo Zhang, Qin Shi   +12 more
wiley   +1 more source

Integrated Transcriptomic Analysis Identifies Core Hub Genes Regulating Mammary Gland Traits (Milk Quality/Lactation) in Dairy Livestock: <i>Bos taurus</i> and <i>Ovis aries</i>. [PDF]

Genes (Basel)
Zhang Q, Yang L, Li Y, Gu P, Si R, Li S, Zhu L, Zhang W.   +7 more
europepmc   +1 more source

A concept for a new approach to combined oral contraception from adolescence to perimenopause: Continuous use of the oral GnRH antagonist Relugolix and the fetal estrogen Estetrol

Acta Obstetricia et Gynecologica Scandinavica, Volume 105, Issue 4, Page 568-574, April 2026.
It is expected that the relugolix estetrol combination RE4W will enable women to control their fertility and prevent menstrual cycle related problems, while offering a smooth transition through perimenopause into the postmenopause and decrease the risk of breast cancer.
Herjan J. T. Coelingh Bennink, Karolina Afors, Luis Bahamondes, Alessandra Graziottin, Deborah Bateson, Teresa Bombas, Yutaki Osuga, Santiago Palacios, Carolyn L. Westhoff, Kristina Gemzell‐Danielsson   +9 more
wiley   +1 more source

Microbe-associated molecular patterns differentially mediate carcinogenic alterations of the breast tissue in the context of obesity. [PDF]

Neoplasia
Gaber M, Moulden LM, Wilson AS, Payne V, Holmes J, Neary K, Peoples A, Duet ML, Katz AJ, Vidi PA, Cook KL.   +10 more
europepmc   +1 more source

Kisspeptin Restores Placental mTOR Signaling and Improves Glucose Homeostasis Mediators Disrupted by Maternal Hypothyroidism in Rats

Acta Physiologica, Volume 242, Issue 4, April 2026.
ABSTRACT Aim Reduced placental mTOR signaling is associated with intrauterine growth restriction and impaired maternal and placental metabolism. Since maternal hypothyroidism induces intrauterine growth restriction, and maternal treatment with kisspeptin‐10 (Kp10) has been shown to improve feto‐placental development in hypothyroid rats, this study ...
Bianca Reis Santos, Jeane Martinha dos Anjos Cordeiro, Luciano Cardoso Santos, Cleisla Souza Oliveira, Maria Clara Pascoal Santos Alvarez, Natália Panhoca Rodrigues, Jorge Lopez‐Tello, Amanda N. Sferruzzi‐Perri, Rogéria Serakides, Juneo Freitas Silva   +9 more
wiley   +1 more source

Overexpression of mitofusin 2 ameliorates inflammation and oxidative stress in lipopolysaccharide-induced mastitis model by regulating phosphofurin acidic cluster sorting protein 2. [PDF]

Animal Model Exp Med
Zhou X, Zhang Y, Ma H, Fu S, Liu J, Guo W, Tian X, Huang B.   +7 more
europepmc   +1 more source

Trefoil Factor‐3 Is a Hypoxia‐Triggered Pro‐Tumorigenic Factor in Hepatoblastoma

Liver International, Volume 46, Issue 4, April 2026.
ABSTRACT Background & Aims Hepatoblastoma (HB) is the most common malignant liver tumour in children. Despite improved survival in low‐risk disease, outcomes for advanced or relapsed HB remain poor, emphasising the need for new therapeutic targets.
Luz A. Martínez‐Pérez, M. Ujue Latasa, Iker Uriarte, Amaya López‐Pascual, Jasmin Elurbide, Pavel Strnad, Sona Frankova, Eva Sticova, Ondrej Fabian, Maria Arechederra, Eva Santamaria, Josepmaria Argemi, Bruno Sangro, Beatrice Foglia, Maurizio Parola, Melva Gutiérrez‐Angulo, Stefano Cairo, Ramón Bataller, Pau Sancho‐Bru, Maria L. Martinez‐Chantar, Jose J. G. Marin, Andrea Castaneda, Carolina Armengol, Carmen Berasain, Maite G. Fernandez‐Barrena, Matias A. Ávila   +25 more
wiley   +1 more source

Phytosphingosine contributes gut microbiota metabolism to alleviate low-grade endotoxemia-induced mastitis. [PDF]

Microbiome
Zhao Y, Li H, Xu J, Li H, Bao L, Wu K, Qiu M, Yu H, Shang S, He Y, Yuan C, Zhang N, Hu X, Fu Y, Li W, Zhao C, Wang J.   +16 more
europepmc   +1 more source

AGE VARIABILITY OF MAMMARY GLAND HISTOSTRUCTURE IN DAIRY AND NON-DAIRY ANIMALS OF DIFFERENT BREEDS AND ORIGIN [PDF]

sel'skokhozyaistvennaya Biologiya, 2019
openaire   +1 more source

Evaluating the Efficacy of Polyphenol‐Enriched Plant Extracts and Pathway Modulators in the Bone Marrow to Suppress Breast Cancer Progression

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
The combined therapy decreased inflammatory and angiogenic signaling and altered bone marrow cell profiles linked to tumor dormancy, indicating a potential approach to limit disease progression and reduce relapse risk in breast cancer. ABSTRACT Disseminated tumor cells (DTCs) in the bone marrow can survive in a dormant state and later reawaken to drive
Hayarpi Javrushyan, Gayane Petrosyan, Marika Mróz, Barbara Kusznierewicz, Yem Alharithi, Mikayel Ginovyan, Alina Maloyan, Nikolay Avtandilyan   +7 more
wiley   +1 more source