Results 61 to 70 of about 4,931,712 (128)

Bone Metastasis: Molecular Mechanisms, Clinical Management, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
This figure emphasizes current understanding of the regulatory networks, approach of diagnose, available preclinical models and clinical management of bone metastasis. to guide future therapeutic development. A deep understanding of these aspects enables the prevention of bone metastasis and the implementation of effective therapeutic strategies ...
Jingyuan Wen, Binghua Li, Shengjia Wang, Yongzhong Yao, Zhao Huang, Decai Yu   +5 more
wiley   +1 more source

Dermoscopic features of mammary Paget's disease: a retrospective case-control study by the International Dermoscopy Society

, 2019
Mammary Paget's disease (MPD) is a rare intraepidermal adenocarcinoma of the nipple-areola complex, associated with an underlying breast cancer in approximately 90% of cases. Delayed diagnosis of MPD is common.
Stinco, G, Blum, A, S. Puig, Lazaridou, E, Errichetti, E, Savoia, F, Zalaudek, I, S. Lanssens, G. Argenziano, F. Savoia, Moscarella, E, E. Moscarella, Sinz, C, I. Zalaudek, Longo, C, Apalla, Z, Kyrgidis, A, Tschandl, P, C. Sinz, Lanssens, S, E. Lazaridou, E. Errichetti, A. Blum, P. Tschandl, G. Stinco, Kittler, H, J. Malvehy, Puig, S, A. Lallas, Stolz, W, Malvehy, J, H. Kittler, Z. Apalla, Argenziano, G, C. Longo, A. Kyrgidis, W. Stolz, Lallas, A   +37 more
core   +1 more source

Single‐Center Epidemiological Analysis of Malignant Transformation With Skin Ulcers in Outpatients

International Wound Journal, Volume 23, Issue 1, January 2026.
ABSTRACT Investigate the epidemiological characteristics of outpatients initially diagnosed with skin ulcers who were ultimately confirmed to have cutaneous malignant tumours, and provide a diagnostic and therapeutic basis for the occurrence of secondary diseases in chronic wounds.
Yaoyao Kong, Haixia Wang, Nan Cao, Pengcheng Huai, Zhenzhen Wang, Chaoqi Zuo, Xueqing Wang, Yilei Wu, Yongxia Liu, Shengli Chen, Hong Liu, Guangliang Zhang   +11 more
wiley   +1 more source

Polarized dermoscopy of mammary Paget disease Dermatoscopia da doença de Paget mamária

Anais Brasileiros de Dermatologia, 2013
Mammary Paget's disease is a rare intraepithelial adenocarcinoma, located on the nipple/areola complex, highly associated with breast cancer. Although the international literature emphasizes the dermatoscopic pattern of mammary Paget's disease pigmented ...
Giselly Silva Neto de Crignis, Luciana de Abreu, Alice Mota Buçard, Carlos Baptista Barcaui   +3 more
doaj  

Cutaneous Metastasis: A Retrospective Clinicopathological and Prognostic Analysis of 62 Patients From a Tertiary Center in China

Dermatologic Therapy, Volume 2026, Issue 1, 2026.
Background Cutaneous metastases are uncommon but clinically significant manifestations of internal malignancies and may indicate advanced disease or, in certain cases, represent the initial sign of cancer. Their variable clinical and histopathologic presentations can pose diagnostic challenges, particularly when the primary tumor is unknown.
Qiannan Jia, Xinran Li, Jun Li, Suraiya Saleem   +3 more
wiley   +1 more source

Paget'S disease of the skin. A unifying concept of histogenesis

, 1982
Utilizing the peroxidase antiperoxidase technique we explored the presence and the distribution of carcinoembryonic antigen (CEA) in seven cases of mammary and sixteen of extramammary Paget'S disease of skin.
Ziegels‐Weissman, Jocelyne, Penneys, Neal S, Girtanner, Robert E, Nadji, Mehrdad, Morales, Azorides R   +4 more
core   +1 more source

ß1 integrins regulate mammary gland proliferation and maintain the integrity of mammary alveoli [PDF]

, 2005
Integrins are cell adhesion receptors which mediate interactions between the extracellular matrix and the actin cytoskeleton. They are heterodimers composed of α and β subunits. As adhesion receptors, integrins are important for cell-cell and cell-matrix
Li, Na
core   +1 more source

The Roles of MicroRNAs, Oncogenes, and Tumor Suppressor Gene Molecular Subtypes of Breast Cancer: Therapeutic Potential of Pharmaceutical and Natural Products

International Journal of Breast Cancer, Volume 2026, Issue 1, 2026.
Background Breast cancer (BC) is the most common malignancy among women, with 2.3 million new cases and over 670,000 deaths annually. Despite advances in detection and therapy, relapse, metastasis, and resistance remain significant challenges. Tumor suppressor genes (TSGs) regulate abnormal cell division, whereas oncogenes, which arise from proto ...
Md. Sadikuj Jaman, Md. Maniruzzaman, Md. Rokibul Hasan Bhuiyan, Md Shajedul Haque, Irfan Ahmad   +4 more
wiley   +1 more source

Immunohistochemical tracking of an immune response in mammary Paget's disease

, 2008
Dendritic cells (DC) are the most potent antigen-presenting cells of the organism. They are specialized to capture, process, and present antigen via the MHC class II as well as the MHC class I pathways to CD4+ and CD8+ T cells, respectively. This results
Haybaeck, J, Langhoff, E, Peter Obrist, Lebecque, S, Nikolaus Romani, Sem Saeland, Brunhuber, T, Saeland, S, Thomas Brunhuber, Johannes Haybaeck, Schäfer, G, Serge Lebecque, Gregor Mikuz, Mikuz, G, Romani, N, Eric Langhoff, Georg Schäfer, Obrist, P   +17 more
core   +1 more source

Patterns of Postmastectomy Radiotherapy in Immediate Breast Reconstruction—Results From the iBRA‐2 Cohort Study

International Journal of Breast Cancer, Volume 2026, Issue 1, 2026.
Purpose Long‐term data indicate that postmastectomy radiotherapy (PMRT) is associated with improved overall survival in node‐positive breast cancer patients. Immediate breast reconstruction (IBR) remains controversial in the context of planned PMRT, but rates of IBR are increasing.
Tim Rattay, Adam Trickey, Rachel L. O’Connell, Rajiv V. Dave, Joanna Skillman, Nicola L. P. Barnes, Matthew D. Gardiner, Chris Holcombe, Shelley Potter, Ivana Ribeiro   +9 more
wiley   +1 more source