Results 31 to 40 of about 132 (118)

A clinicopathological and immunohistochemical profile of primary extra mammary paget's Disease in skin of colour: A case series

Indian Journal of Dermatology, 2023
Extramammary Paget's disease is an intraepithelial neoplasm, usually found in areas rich in apocrine gland concentration. The clinical features, histopathology, immunohistochemistry and management details of five patients (F = 3, M = 2) have been ...
Subhra Dhar, Divya Gupta, Aditi Chakraborty, Rajib Malakar, Sandipan Dhar   +4 more
doaj   +1 more source

Knowledge gaps in tubular gut tumours: a critical appraisal of the 6th edition of the World Health Organization classification of tumours

The Journal of Pathology, Volume 270, Issue 1, Page 4-22, September 2026.
Abstract Gastrointestinal cancer is a global health problem. In the new 6th edition of the World Health Organization Classification of Tumours (WCT) of the Digestive System, updated evidence and guidance is provided for the aetiology, pathogenesis, diagnosis, classification, grading, staging and prognosis of these tumours.
Iris D Nagtegaal, Elizabeth A Montgomery, Alexandros D Polydorides, Anthony J Gill, Motohiro Kojima, Mark J Arends   +5 more
wiley   +1 more source

Traditional Chinese Medicine Combined With Chemotherapy for Mammary Paget's Disease With Multifocal Heterogeneous Breast Cancer: A Case Report

Clinical Case Reports, Volume 14, Issue 8, August 2026.
This flowchart systematically outlines the full diagnostic and therapeutic pathway of mammary Paget's disease with ipsilateral multifocal breast cancer, covering preoperative radiological assessment, postoperative histopathological confirmation of inter‐lesional molecular heterogeneity, individualized multimodal treatment, recurrence‐free follow‐up ...
Hongyu Cheng, Jiayin Tang, Chang Yao
wiley   +1 more source

Mammary Fibroblasts Secrete Damage Associated Molecular Patterns Through Extracellular Vesicles in Response to Ionizing Radiation

Journal of Extracellular Biology, Volume 5, Issue 5, May 2026.
We show that ionizing radiation (IR)‐induced damage in mammary fibroblasts results in a senescence‐like phenotype including enhanced EV and cytokine secretion. Proteomic profiling revealed that IR‐induced EVs are enriched with damage associated molecular patterns (DAMPs) and pro‐inflammatory mediators.
Greg Berumen Sánchez, Purvi Patel, Preston Gomez‐Crase, Chloe Kim, Kevin C. Corn, Kristie L. Rose, Marjan Rafat   +6 more
wiley   +1 more source

Rescuing Mitochondrial Dysfunction in Macrophages Prevents Osteonecrosis of the Jaw in Anti‐Resorptive Therapy

Advanced Science, Volume 13, Issue 11, 23 February 2026.
Schematic model showing the suggested mechanism that ZA induces classical activation of macrophages by impairing mitochondrial biofunction and inhibiting mitochondrial clearance to contribute to the pathological process of BRONJ. RAPA‐loaded nanoparticles ZDPR has shown potential in alleviating BRONJ lesions as well as treating osteoporosis or ...
Hang Zhang, Xin Shen, Haiyang Liu, Xinxi Yuan, Mumin Cao, Xuepeng Lv, Ziji Ling, Songsong Guo, Rongyao Xu, Xiang Li, Hongbing Jiang   +10 more
wiley   +1 more source

Bone Metastasis: Molecular Mechanisms, Clinical Management, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
This figure emphasizes current understanding of the regulatory networks, approach of diagnose, available preclinical models and clinical management of bone metastasis. to guide future therapeutic development. A deep understanding of these aspects enables the prevention of bone metastasis and the implementation of effective therapeutic strategies ...
Jingyuan Wen, Binghua Li, Shengjia Wang, Yongzhong Yao, Zhao Huang, Decai Yu   +5 more
wiley   +1 more source

Clinicopathologic evaluation of mammary Paget′s disease

Indian Journal of Dermatology, 2008
Mammary and extramammary Paget′s diseases are rare neoplasms of epidermis and mucosal epithelium. Due to their nonspecific and variable clinical view, they have differential diagnosis with eczema, melanoma, Bowen′s disease, etc. To the best
Meibodi Naser, Ghoyunlu Vahid, Javidi Zari, Nahidi Yalda   +3 more
doaj  

Multimodal Imaging Detection of Difficult Mammary Paget Disease: Dermoscopy, Reflectance Confocal Microscopy, and Line-Field Confocal–Optical Coherence Tomography

Diagnostics
Mammary Paget disease (MPD) is a rare cutaneous malignancy associated with underlying ductal carcinoma in situ (DCIS) or invasive ductal carcinoma (IDC).
Carmen Cantisani, Gianluca Caruso, Alberto Taliano, Caterina Longo, Giuseppe Rizzuto, Vito D’Andrea, Pawel Pietkiewicz, Giulio Bortone, Luca Gargano, Mariano Suppa, Giovanni Pellacani   +10 more
doaj   +1 more source

Adenomatose erosiva do mamilo Erosive adenomatosis of the nipple

Anais Brasileiros de Dermatologia, 2011
A adenomatose erosiva do mamilo é uma complexa proliferação benigna mamária que pode ser confundida com neoplasias malignas da mama. A apresentação típica cursa com descarga mamária, eritema, erosão e formação de crostas.
Mayara Schulze Cosechen, Adma Silva de Lima Wojcik, Flávio Meingast Piva, Betina Werner, Sérgio Zuneda Serafini   +4 more
doaj   +1 more source

Single‐Center Epidemiological Analysis of Malignant Transformation With Skin Ulcers in Outpatients

International Wound Journal, Volume 23, Issue 1, January 2026.
ABSTRACT Investigate the epidemiological characteristics of outpatients initially diagnosed with skin ulcers who were ultimately confirmed to have cutaneous malignant tumours, and provide a diagnostic and therapeutic basis for the occurrence of secondary diseases in chronic wounds.
Yaoyao Kong, Haixia Wang, Nan Cao, Pengcheng Huai, Zhenzhen Wang, Chaoqi Zuo, Xueqing Wang, Yilei Wu, Yongxia Liu, Shengli Chen, Hong Liu, Guangliang Zhang   +11 more
wiley   +1 more source