Results 51 to 60 of about 132 (118)

A Case Report of Short‐Term Metastasis After Surgery for Mammary Paget's Disease

Clinical Case Reports, Volume 13, Issue 12, December 2025.
ABSTRACT Mammary Paget's disease (MPD) with ductal carcinoma in situ (DCIS) pathology can metastasize rapidly. HER2‐positive status likely drives aggression, warranting early postoperative systemic imaging and close surveillance. Anti‐HER2 agents require proactive toxicity management.
Chao Wang, Baiyi Yan, Jing Wang, Jiahui Zhou, Dongxu Li, Xiaofang Gao, Yong Pan   +6 more
wiley   +1 more source

3D In Vitro Models of Breast Cancer: Current Challenges and Future Prospects Toward Recapitulating the Microenvironment and Mimicking Key Processes

Advanced Biology, Volume 9, Issue 11, November 2025.
In vitro cancer models are advantageous for studying important processes such as tumorigenesis, cancer growth, invasion, and metastasis. The complexity and biological relevance increase depending on the model structure, organization, and composition of materials and cells.
Kyndra S. Higgins, Ah Joung Yu, Cheryl T. Gomillion   +2 more
wiley   +1 more source

Breast and Nipple Dermatoses During Lactation

Australasian Journal of Dermatology, Volume 66, Issue 7, Page e386-e407, November 2025.
ABSTRACT Lactation and breastfeeding can present both psychological and physical challenges for breastfeeding mothers. In addition, many nursing mothers will also suffer from breast and nipple dermatoses during this period, compounding these difficulties. Common causes of breast and nipple dermatitis during lactation include eczema, psoriasis, mastitis,
Hamish Moore, Annabel Stevenson
wiley   +1 more source

Comprehensive management of vulvovaginal cancers

CA: A Cancer Journal for Clinicians, Volume 75, Issue 5, Page 410-435, September/October 2025.
Abstract Vulvar and vaginal cancers represent rare malignancies, with an incidence of 2.7 per 100,000 women for vulvar cancer, predominantly affecting women older than 60 years, although rising rates are observed in younger demographics. Approximately 90% of vulvar cancers are squamous cell carcinoma and frequently are associated with human ...
Angélica Nogueira‐Rodrigues, Maaike H. M. Oonk, Domenica Lorusso, Brian Slomovitz, Mario M. Leitão Jr, Glauco Baiocchi   +5 more
wiley   +1 more source

Expression of Desmogleins in Paget Cells of Mammary and Extramammary Paget's Disease.

The Kurume Medical Journal, 1997
Sagebiel (1969) electronmicroscopically observed that desmosomes are present between adjacent Paget cells, as well as between Paget cells and adjacent keratinizing epidermal cells. Desmosomes contain the proteins desmoglein (Dsg) and desmocollin as their transmembrane components, and Dsg has three isotypes.
MORI, OSAMU, KARASHIMA, TADASHI, MATSUO, KEIZO, HASHIMOTO, TAKASHI   +3 more
openaire   +3 more sources

Cancer of the vulva: 2025 update

International Journal of Gynecology &Obstetrics, Volume 171, Issue S1, Page 36-47, September 2025.
Abstract Vulvar cancer is an uncommon gynecological malignancy primarily affecting postmenopausal women. No specific screening exists and the most effective strategy to reduce the incidence of vulvar cancer is the opportune treatment of predisposing and preneoplastic lesions associated with its development.
Alexander B. Olawaiye, Mauricio A. Cuello, Sushil Beriwal, Linda J. Rogers   +3 more
wiley   +1 more source

Metastatic Extramammary Paget’s Disease of Scrotum Responds Completely to Single Agent Trastuzumab in a Hemodialysis Patient: Case Report, Molecular Profiling and Brief Review of the Literature

Case Reports in Oncological Medicine, 2015
Extramammary Paget’s disease (EMPD) is a rare cancer. Although EMPD is usually noninvasive and treated with local therapy, once metastatic the prognosis of EMPD is poor and treatment options are limited.
Peter Barth, Essel Dulaimi Al-Saleem, Kristin W. Edwards, Sherri Z. Millis, Yu-Ning Wong, Daniel M. Geynisman   +5 more
doaj   +1 more source

Fibronectin Fibers Progressively Lose Their Tension in Invasive Human Breast Carcinoma while Being Tensed in DCIS and Healthy Breast Tissue

Advanced Science, Volume 12, Issue 31, August 21, 2025.
Extracellular matrix remodeling is crucial in cancer progression. Using a peptide to probe the tension of ECM fibers, it was found that Fibronectin fibers gradually lose tension as human breast carcinoma progresses, while their tension is maintained in ductal carcinoma in situ (DCIS), the non‐invasive precursor of breast cancer. This loss of tension is
Arnaud Miéville, Charlotte M. Fonta, Cornelia Leo, Lucine Christe, Jörg Goldhahn, Gad Singer, Viola Vogel   +6 more
wiley   +1 more source

Paget disease.Three cases of mammary Paget disease.

Skin Cancer, 1991
最近10年間に当科で経験した乳房Paget病の3例を報告した。症例1は34歳女性, 右乳頭とその周辺の硬く腫脹した紅色局面。症例2は69歳女性, 点状の鱗屑を付する右乳頭の腫脹。症例3は64歳女性, 左乳頭と周辺乳輪に厚い痂皮を付する紅色局面。組織学的に症例1, 2は面皰癌の所見が認められたが, 症例3は異型な乳管を認めるのみであった。症例2は臨床的に湿疹様の軽微な変化しか呈しておらず早期の生検の必要性を認識した。
openaire   +2 more sources

Phosphate in Physiological and Pathological Mineralization: Important yet Often Unheeded

MedComm, Volume 6, Issue 7, July 2025.
Phosphate serves as a building block for physiological mineralization, and as a signaling molecule that regulates the activity of mineralizing cells. The disturbance in these processes could induce a series of pathological mineralization, with abnormal mineralization of hard tissues and ectopic mineralization of soft tissues being the most ...
Wen Qin, San‐yang Yu, Jia‐lu Gao, Jian‐fei Yan, Qian‐qian Wan, Shuai‐lin Jia, Franklin Tay, Kai Jiao, Lina Niu   +8 more
wiley   +1 more source