Results 51 to 60 of about 5,831 (173)

N6‐Methyladenosine in Inflammatory Bowel Disease: An Emerging Regulator of Pathogenesis and a Novel Therapeutic Frontier

open access: yesiMetaMed, EarlyView.
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the intestine associated with an imbalance in intestinal homeostasis. m6A‐modifying enzymes, consisting of m6A writers, erasers and readers, plays a pivotal role in the pathogenesis and progression of IBD by affecting four intestinal barriers, including the intestinal mechanical ...
Jiaxian Guo   +4 more
wiley   +1 more source

Functionally redundant RXLR effectors from Phytophthora infestans act at different steps to suppress early flg22-triggered immunity.

open access: yesPLoS Pathogens, 2014
Genome sequences of several economically important phytopathogenic oomycetes have revealed the presence of large families of so-called RXLR effectors.
Xiangzi Zheng   +10 more
doaj   +1 more source

Gut microbiota dysbiosis‐mediated gut NLRP3 inflammasome activation exacerbates corticospinal tract injury after intracerebral hemorrhage

open access: yesInterdisciplinary Medicine, EarlyView.
Schematic depicting a gut‐brain pathway that exacerbates CST injury after ICH. Gut Microbiota Dysbiosis‐Mediated Gut NLRP3 Inflammasome Activation Exacerbates Corticospinal Tract Injury After Intracerebral Hemorrhage. Abstract Intracerebral hemorrhage (ICH) causes severe neurological deficits largely attributable to corticospinal tract (CST) injury ...
Meiqin Zeng   +11 more
wiley   +1 more source

MAMP-triggered Medium Alkalinization of Plant Cell Cultures

open access: yesBio-Protocol, 2020
Plants recognize a wide variety of microbial molecules to detect and respond to potential invaders. Recognition of Microbe-Associated Molecular Patterns (MAMPs) by cell surface receptors initiate a cascade of biochemical responses that include, among ...
Gabriel Fiorin   +4 more
doaj   +1 more source

Dynamin-Related Proteins Enhance Tomato Immunity by Mediating Pattern Recognition Receptor Trafficking

open access: yesMembranes, 2022
Pattern recognition receptor (PRR) trafficking to the plasma membrane and endocytosis plays a crucial role in pattern triggered immunity (PTI). Dynamin-related proteins (DRPs) participate in endocytosis and recycling.
Meirav Leibman-Markus   +5 more
doaj   +1 more source

Microbial burden of periodontal diseases and its clinical application: The stage, grade, and furcation matter

open access: yesJournal of Periodontology, EarlyView.
Abstract Background Periodontal diseases are associated with dysbiotic oral microbial communities, but clinically applicable measures that reflect microbial burden across disease severity and progression remain limited. This study aimed to assess the oral microbial burden of periodontal diseases by evaluating salivary and subgingival lipopolysaccharide
Anbo Dong   +8 more
wiley   +1 more source

The plant pathogen Pseudomonas syringae pv. tomato is genetically monomorphic and under strong selection to evade tomato immunity.

open access: yesPLoS Pathogens, 2011
Recently, genome sequencing of many isolates of genetically monomorphic bacterial human pathogens has given new insights into pathogen microevolution and phylogeography.
Rongman Cai   +18 more
doaj   +1 more source

Harnessing plant susceptibility genes into strategies for enhanced disease resistance

open access: yesNew Plant Protection, EarlyView.
Integrated model of S gene modules in plant pathogen interactions. This model summarises representative host susceptibility modules that can be exploited by bacterial, fungal and viral pathogens. In the bacterial infection module, Xanthomonas transcription activator‐like effectors activate OsSWEET14 through effector‐binding elements in its promoter ...
Can Chen   +4 more
wiley   +1 more source

Crosstalk between Calcium and ROS Signaling during Flg22-Triggered Immune Response in Arabidopsis Leaves

open access: yesPlants, 2021
Calcium and reactive oxygen species (ROS) are two of the earliest second messengers in response to environmental stresses in plants. The rise and sequestration of these messengers in the cytosol and apoplast are formed by various channels, transporters ...
Matthew J. Marcec, Kiwamu Tanaka
doaj   +1 more source

Oral microbiome and homeostatic regulation of periodontal health: From dysbiosis to precision intervention

open access: yesVIEW, EarlyView.
Periodontal homeostasis is maintained by coordinated interactions between the oral microbiome and host. Dysbiosis disrupts this ecological balance and contributes to periodontal disease, whereas multi‐omics, artificial intelligence, and microbiome‐based interventions provide emerging opportunities for precision diagnosis, ecological restoration, and ...
Xu Liu   +11 more
wiley   +1 more source

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