Results 81 to 90 of about 35,788 (281)
GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy
Advanced Science, EarlyView.Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu +11 more
wiley +1 more source
Advanced Science, EarlyView.Constitutive PRKCN expression is driven by super‐enhancers and modulated by NF‐κB signaling in multiple myeloma (MM). PRKCN activates mTORC1/2‐IRF4 signaling axis and favors tumor cell growth independently of its kinase activity. IRF4 reciprocally promotes PRKCN transcription, creating a feed‐forward loop.
Koukou Tang +12 more
wiley +1 more source
cuteHap: Haplotype‐Aware Structural Variant Detection in Phased Long‐Read Sequencing Data
Advanced Science, EarlyView.cuteHap is a haplotype‐aware structural variant detection method designed for phased long‐read sequencing. By employing self‐adaptive clustering and credibility‐prioritized beam search algorithms, cuteHap generates accurate haplotype‐resolved calls and outperforms state‐of‐the‐art tools.
Shuqi Cao +7 more
wiley +1 more source
Manageability comparison: Oracle database 10g and Oracle 9i database [PDF]
In this paper we performed a basic and common DBA tasks on the two products and measured the time taken and the steps required to complete each task, to assess their relative manageability. The time taken to complete the tasks was then weighted according
Lungu, Ion, Vatuiu, Teodora
core +1 more source
Advanced Science, EarlyView.The inhibitory immune checkpoints HLA‐G and CD47 are expressed on certain tumor types and inhibit immune cells in the tumor microenvironment. DSP216 binds specifically to cancer cells expressing both HLA‐G and CD47, and blocks their inhibitory signaling.
Lisa J. Jacob +12 more
wiley +1 more source
Drawing on the Arts to Enhance Salutogenic Coping With Health-Related Stress and Loss
Frontiers in Psychology, 2018 The connection between art therapy and specific theories of positive psychology such as Antonovsky’s theory of salutogenic sense of coherence (SOC) has been less articulated in the literature.
Ephrat Huss, Tali Samson
doaj +1 more source
AfL with APP: developing collaborative school-based approaches: guidance for senior leaders (National Strategies) [PDF]
, 2009 "Schools are now taking forward Assessing Pupils' Progress (APP) as a continuing priority to personalise learning for all pupils across all phases, plan for progression and overcome barriers.
core
, 2003 Quality of service in network communication is mainly assured by traffic management consisting in a variety of protocols and mechanisms whose role is to prevent the network from being congested. Traffic management has been a very active area of research for two decades following the conception of packet-switched integrated services networks, such as ...
KARLSSON G +21 more
openaire +5 more sources
Development‐based In Vivo Bioreactor Strategy for Challenging Senescent Bone Reconstruction
Advanced Science, EarlyView.We present a development‐based in vivo bioreactor strategy to generate rejuvenated bone grafts (vBR‐Bone) within aged hosts. By enclosing vBR‐Bone fragments within an asymmetric biomimetic periosteum, segmental femoral defects in aged mice were successfully repaired within 6 weeks. Mechanistically, the multifactors of vBR‐Bone reconstitute a remodeling
Wenchao Zhang +9 more
wiley +1 more source
Enabling Disaster Resilient 4G Mobile Communication Networks
, 2014 The 4G Long Term Evolution (LTE) is the cellular technology expected to outperform the previous generations and to some extent revolutionize the experience of the users by taking advantage of the most advanced radio access techniques (i.e. OFDMA, SC-FDMA,
Gomez, Karina +3 more
core +1 more source