Results 61 to 70 of about 782,228 (307)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Consumer-directed services: lessons and implications for integrated systems of care

open access: yesInternational Journal of Integrated Care, 2003
Over the past decade, policy makers in developed countries have begun to pay increasing attention to reform of the long-term care system for the frail elderly and younger people with disabilities.
Dennis L. Kodner
doaj   +3 more sources

The Financial Implications of Coverage of Smoking Cessation Treatment by Managed Care Organizations

open access: yesInquiry: The Journal of Health Care Organization, Provision, and Financing, 2004
This paper presents results from a simulation of the financial impact and cost effectiveness of smoking cessation in a hypothetical managed care organization (MCO), using data from three large managed care organizations and from existing literature. With
Kenneth E. Warner   +2 more
doaj   +1 more source

Disease management projects and the Chronic Care Model in action: baseline qualitative research

open access: yesBMC Health Services Research, 2012
Background Disease management programs, especially those based on the Chronic Care Model (CCM), are increasingly common in the Netherlands. While disease management programs have been well-researched quantitatively and economically, less qualitative ...
Walters Bethany   +3 more
doaj   +1 more source

Children's Health Coverage Facts and Figures [PDF]

open access: yes, 2009
Outlines trends in children's health insurance in California. Reviews 1997-2009 milestones in expanding coverage and examines uninsurance rates; eligibility for and enrollment in public programs; sources of coverage by income and age; and access to ...
Dana Hughes, Michael R. Cousineau
core  

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

open access: yesMolecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix   +13 more
wiley   +1 more source

Medicare Advantage Special Needs Plans for Dual Eligibles: A Primer [PDF]

open access: yes, 2008
Identifies the key issues behind the goal of a new plan for people eligible for both Medicare and Medicaid -- to offer the full array of Medicare, Medicaid, and supplemental benefits through a single plan -- and outlines progress thus ...
Cynthia H. Woodcock
core  

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Identification and Assessment of Children and Youth with Special Health Care Needs in Medicaid Managed Care: Approaches from Three States [PDF]

open access: yes, 2014
Increasingly, states are relying on managed care delivery systems to serve Medicaid enrollees that have historically been exempt from enrollment in managed care, such as children and youth with special health care needs (CYSHCN).
Joanne Jee, Julien Nagaragan
core  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

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