Results 91 to 100 of about 20,384,351 (344)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Influencing irrigation policy in India [PDF]

Irrigation managementPolicyWater conservationGroundwater ...
International Water Management Institute (IWMI).
core  

Linking forest management and biodiversity indicators to strengthen sustainable forest management in Europe

, 2020
Janine Oettel, Katharina Lapin
openalex   +1 more source

An Add-On Model Predictive Control Strategy for the Energy Management of Hybrid Electric Tractors [PDF]

, 2023
Stefano Radrizzani, Giulio Panzani, Luca Trezza, Solomon Pizzocaro, Sergio M. Savaresi   +4 more
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Development of effective water-management institutions: final report, volume I, executive summary [PDF]

Water resources development / Water resource management / Institutional development / Development ...
International Water Management Institute (IWMI).
core  

Medical Utilization Review Using Indicators “ORTHOPAEDICS†in Orthopaedic Inpatients under Universal Coverage Policy Admitted to Siriraj Hospital

Siriraj Medical Journal, 2006
Objective: Utilization review is very important especially in universal coverage policy. In Siriraj Hospital the utilization review began in 2002, and the Department of Orthopaedic Surgery developed the indicators “ORTHOPAEDICS†to assess the ...
UMOST (Utilization Management Orthopaedic Siriraj Team)
doaj  

European Code Against Cancer, 5th edition – hormone replacement therapy, other common medical therapies and cancer

Molecular Oncology, EarlyView.
The 5th edition of the European Code Against Cancer (ECAC5) contains 14 recommendations on cancer prevention. Here, we update the cancer prevention recommendations regarding the use of hormone replacement therapy (HRT), which is positioned as recommendation number 13 of the ECAC5.
Mangesh A. Thorat, Marc Arbyn, David Baldwin, Xavier Castells, Solveig Hofvind, Urska Ivanus, Carlo Senore, Esther Toes‐Zoutendijk, Carlijn van der Aalst, Carlos Canelo‐Aybar, Fiorella Karina Fernández‐Sáenz, Ariadna Feliu, Hajo Zeeb, Andre L. Carvalho, Erica D'Souza, David Ritchie, Carolina Espina, Iris Lansdorp‐Vogelaar, Andrea DeCensi   +18 more
wiley   +1 more source

Does food trade save water?: the potential role of food trade in water scarcity mitigation [PDF]

Food production / Trade / Water ...
International Water Management Institute (IWMI).
core  

Management [PDF]

Anesthesiology, 2020
openaire   +2 more sources