Results 81 to 90 of about 5,218,208 (307)

Valuing Knowledge Management Impact on Engineering Design Activities [PDF]

Knowledge Management Systems (KMS) have been developed in Engineering Designactivities in order to improve the productivity of these activities. Nevertheless it is still verydifficult to identify the impact of such Systems on the Engineering Design ...
Aurélie Dudezert, Mickaël Gardoni
core  

Integrating descriptions of knowledge management learning activities into large ontological structures: A case study [PDF]

, 2005
Ontologies have been recognized as a fundamental infrastructure for advanced approaches to Knowledge Management (KM) automation, and the conceptual foundations for them have been discussed in some previous reports. Nonetheless, such conceptual structures
García Barriocanal, Elena, Lytras, Miltiadis, Rodríguez González, M. Elena, Sicilia Urbán, Miguel Ángel   +3 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Knowledge organization or information organization : a key component of knowledge management activities [PDF]

, 2004
This paper focuses on the various bibliographic and information retrieval tools and techniques used for information organization, a key activity in a knowledge management process. The paper begins with the existing debate on the very concept of knowledge
Chowdhury, G.
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Biodistribution and dosimetry of the PET radioligand [18F]CHDI-650 in mice for detection of mutant huntingtin aggregates

EJNMMI Research
Background Huntington’s disease (HD) is a rare neurodegenerative disorder caused by an expansion of the CAG trinucleotide repeat in the huntingtin gene which encodes the mutant huntingtin protein (mHTT) that is associated with HD-related ...
Jordy Akkermans, Alan Miranda, Jeroen Verhaeghe, Filipe Elvas, Franziska Zajicek, Jonathan Bard, Longbin Liu, Vinod Khetarpal, Robert Doot, Steven Staelens, Daniele Bertoglio   +10 more
doaj   +1 more source

Indicators for Assessing the Socio-Economic Responsibility of Entrepreneurship in Ukraine [PDF]

Problemi Ekonomiki, 2017
The aim of the article is to determine the main indicators that can be used for assessing the socio-economic responsibility of Ukrainian enterprises, and group these indicators by categories of stakeholders.
Dielini Maryna M.
doaj  

Comparative assessment of anticipated wind power capacities in Bulgaria and Kazakhstan [PDF]

E3S Web of Conferences
This paper presents a detailed comparative analysis of the projected growth in wind power capacities in Bulgaria and Kazakhstan from 2023 to 2030.
Iliev Teodor, Fazylova Alina, Stoycheva Bozhana   +2 more
doaj   +1 more source

Effects of Messaging Framing on the Self-Management Activities and Self-Efficacies of Patients with Type 2 Diabetes Mellitus. [PDF]

Iran J Public Health, 2023
Bao H.
europepmc   +1 more source