Results 81 to 90 of about 19,306,626 (265)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

Corporate social responsibility and management control [PDF]

open access: yes
This paper focuses on the management control processes associated with Corporate Social Responsibility (CSR) issues management in organisations. Following a review of the literature related to management control and CSR, we use a case example of a ...
Alexander Mersereau, Nicolas Mottis
core  

The novel application of optimization and charge blended energy management control for component downsizing within a plug-in hybrid electric vehicle [PDF]

open access: yes, 2012
The adoption of Plug-in Hybrid Electric Vehicles (PHEVs) is widely seen as an interim solution for the decarbonization of the transport sector. Within a PHEV, determining the required energy storage capacity of the battery remains one of the primary ...
James Marco   +5 more
core   +1 more source

Cybernetic Control in a Supply Chain: Wave Propagation and Resonance [PDF]

open access: yesJournal of Systemics, Cybernetics and Informatics, 2006
The cybernetic control and management of production can be improved by an understanding of the dynamics of the supply chains for the production organizations.
Ken Dozier, David Chang
doaj  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

Optimization and intelligent power management control for an autonomous hybrid wind turbine photovoltaic diesel generator with batteries. [PDF]

open access: yesSci Rep, 2023
Rekioua D   +9 more
europepmc   +1 more source

Conflict management approaches, customer expectation evaluation, and customer satisfaction : an empirical investigation [PDF]

open access: yes, 2004
vii, 71 leaves ; 29 cm.This study investigates the potential impacts of different conflict management approaches and expectation evaluation on customer satisfaction.
University of Lethbridge. Faculty of Management   +1 more
core  

Digitalisation of Enterprises Brings New Opportunities to Traditional Management Control

open access: yesBusiness Systems Research, 2017
Background: Advanced information systems have changed the way managers work with planning and performance measurement. Traditional management control concepts such as efficiency have changed in meaning due to these information systems.
Bredmar Krister
doaj   +1 more source

Research of Safety Risk Impact and Management Controls of Electric Vehicle Charging on Power Grid

open access: yes发电技术, 2018
With the government's supporting and incentives policy, the electric vehicle market obtains rapid development, which greatly stimulates the construction and operation of electric vehicle charging facilities.
Junliang WANG   +3 more
doaj   +1 more source

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