Results 41 to 50 of about 3,159,903 (327)
On Evidence-based Risk Management in Requirements Engineering
, 2017 Background: The sensitivity of Requirements Engineering (RE) to the context makes it difficult to efficiently control problems therein, thus, hampering an effective risk management devoted to allow for early corrective or even preventive measures ...
B Boehm +15 more
core +1 more source
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
Discrete Dynamics in Nature and Society, 2022 With the advent of the big data era, information technology and intelligent algorithms are more and more widely used. In the engineering project management industry, big data technology and dynamic modeling have achieved good results.
Xiaowen Zhuang, Chuanbao Wu
doaj +1 more source
OntoMaven: Maven-based Ontology Development and Management of Distributed Ontology Repositories [PDF]
, 2013 In collaborative agile ontology development projects support for modular reuse of ontologies from large existing remote repositories, ontology project life cycle management, and transitive dependency management are important needs.
Paschke, Adrian
core
Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source
Advances in Civil Engineering, 2022 Power engineering is complex, involving many participants, numerous management factors, and different stages. To improve the quality management level of power engineering and realize the standardization of power engineering quality management, power ...
Tai-Ping Yuan +3 more
doaj +1 more source
The suitability of MSP for engineering infrastructure [PDF]
, 2020 This paper arose from empirical investigations of practitioner views of both governance and program definitions together with investigations of practitioner reference documents.
McGrath, Stephen +1 more
core +2 more sources
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Towards an integrated perspective on fleet asset management: engineering and governance considerations [PDF]
, 2008 The traditional engineering perspective on asset management concentrates on the operational performance the assets. This perspective aims at managing assets through their life-cycle, from technical specification, to acquisition, operation including ...
Kivits, Rob +3 more
core +2 more sources
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source