Results 71 to 80 of about 12,428,451 (371)

China and India lead in greening of the world through land-use management

open access: yesNature Sustainability, 2019
Satellite data show increasing leaf area of vegetation due to direct factors (human land-use management) and indirect factors (such as climate change, CO2 fertilization, nitrogen deposition and recovery from natural disturbances).
Chi Chen   +14 more
semanticscholar   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

open access: yesMolecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir   +12 more
wiley   +1 more source

Project management for engineers

open access: yes, 2016
In recent years we have witnessed a rapid growth in the use of project management methods and tools as a means by which organisations achieve their objectives. Projects drive business in industries as diverse as transportation, pharmaceuticals, banking, and hospitals etc.
openaire   +2 more sources

Technical management techniques for identification and control of industrial safety and pollution hazards [PDF]

open access: yes, 1972
Constructive recommendations are suggested for pollution problems from offshore energy resources industries on outer continental shelf. Technical management techniques for pollution identification and control offer possible applications to space ...
Campbell, R.   +4 more
core   +1 more source

Radar Spectrum Engineering and Management: Technical and Regulatory Issues

open access: yesProceedings of the IEEE, 2015
The radio-frequency (RF) electromagnetic spectrum, extending from below 1 MHz to above 100 GHz, represents a precious resource. It is used for a wide range of purposes, including communications, radio and television broadcasting, radionavigation, and ...
H. Griffiths   +6 more
semanticscholar   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

open access: yesMolecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck   +12 more
wiley   +1 more source

Integrated water resources management using engineering measures [PDF]

open access: yesProceedings of the International Association of Hydrological Sciences, 2015
The management process of Integrated Water Resources Management (IWRM) consists of aspects of policies/strategies, measures (engineering measures and non-engineering measures) and organizational management structures, etc., among which engineering ...
Y. Huang
doaj   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

open access: yesMolecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié   +13 more
wiley   +1 more source

RWU Approves Campus Location for New SECCM Labs [PDF]

open access: yes, 2017
With Trustees\u27 approval, RWU plans to break ground in spring on School of Engineering, Computing and Construction Management ...
Fitzpatrick, Edward
core   +1 more source

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