Results 51 to 60 of about 5,063,922 (309)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

DESI Integration and Enterprise Productivity in the EU: A Business Model Innovation Perspective on Digital Transformation

Systems
Digital transformation reshapes firms into more digital, data-driven, and customer-centric organizations. Because it often supports innovation, firms are widely expected to benefit from higher performance and productivity.
Ofelia Ema Aleca, Florin Mihai
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Antecedents of Gacha gaming intention: Extending UTAUT2 with structural video game characteristics

Computers in Human Behavior Reports
Mobile gacha games, featuring chance-based virtual item collections and lottery-like mechanics, have become immensely popular among global youth. Therefore, many game developers are developing new gacha games or implementing gacha mechanics into existing
Adidharma Ekaputra Kesuma, Elfindah Princes   +1 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

A High‐Sensitivity Circulating Nucleic Acid Sequencing Assay for Assessing Treatment Response to Alectinib in a Pediatric Patient With ALK‐Rearranged Non–Small Cell Lung Cancer

Pediatric Blood &Cancer, EarlyView.
Alberto D. Guerra, Nicholas F. Evageliou, Vandana Batra, Kristen L. Dalton, Stephanie Ortel, Usman Ashraf, Tricia R. Bhatti, Lisa J. States, Lea F. Surrey, Theodore W. Laetsch   +9 more
wiley   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

How volatility in the oil market and uncertainty shocks affect Saudi economy: a frequency approach

Humanities & Social Sciences Communications
In this study, spectral Granger causality analysis is employed to investigate the spectral dynamics of uncertainty transmission and its impact on economic growth and financial development in Saudi Arabia from 1993 to 2020.
Haykel Tlili, Kais Tissaoui, Bassem Kahouli, Rabab Triki   +3 more
doaj   +1 more source

Fostering energy communities’ engagement: the role of empowerment and hedonic motivations

Global Sustainability
Non-technical summary Energy communities allow people to produce, share, and manage renewable energy together, helping reduce carbon emissions and decentralize the energy system.
David Moniz, Tiago Oliveira, Catarina Neves   +2 more
doaj   +1 more source

Threats and ensuring information security in crisis management systems

Nowoczesne Systemy Zarządzania, 2019
Constantly progressing technical and technological development has allowed the creation of IT tools, the use of which will positively affect the actions taken by decision-makers.
Michał Jurek, Marcin Staruch
doaj   +1 more source