Results 131 to 140 of about 6,034,145 (367)

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

open access: yesMolecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski   +19 more
wiley   +1 more source

Structural controllability and management of cascading regime shifts [PDF]

open access: yesarXiv
Abrupt transitions in ecosystems can be interconnected, raising challenges for science and management in identifying sufficient interventions to prevent them or recover from undesirable shifts. Here we use principles of network controllability to explore how difficult it is to manage coupled regime shifts.
arxiv  

Four-Step Approach Model of Inspection (FAMI) for Effective Defect Management in Software Development [PDF]

open access: yesarXiv, 2012
IT industry should inculcate effective defect management on a continual basis to deploy nearly a zerodefect product to their customers. Inspection is one of the most imperative and effective strategies of defect management. Nevertheless, existing defect management strategies in leading software industries are successful to deliver a maximum of 96 ...
arxiv  

The Virginia Wetlands Report No. 94-9 [PDF]

open access: yes, 1994
Birds of the Eastern Shore. Julie G.Bradshaw Virginia’s Eastern Shore: Gone to the Birds. Jill Barnard VIMS Wetlands Education Program Notes. Maryann Wohlgemuth Bluefish. Lyle Varnell The Virginia Geographic Information Network (VGIN).
Center for Coastal Resources Management   +1 more
core   +1 more source

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

open access: yesFEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi   +2 more
wiley   +1 more source

Derelict Crab Pots in the Chesapeake Bay [PDF]

open access: yes, 2010
Rivers & Coast is a periodic publication of the Center for Coastal Resources Management, Virginia Institute of Marine Science. The goal of Rivers & Coast is to keep readers well informed of current scientific understanding behind key environmental issues
Center for Coastal Resources Management, Virginia Institute of Marine Science
core   +1 more source

Establishment and biological characterization of radioresistant colorectal cancer cell lines

open access: yesFEBS Open Bio, EarlyView.
Under ionizing radiation exposure, radiation‐sensitive cancer cells exhibit oxidative stress and DNA damage, while radiation‐resistant cancer cells exhibit strong antioxidant properties and DNA damage repair. Radiotherapy resistance is a major cause of recurrence and metastasis in colorectal cancer (CRC).
Tian‐Yin Qu   +10 more
wiley   +1 more source

Nagios Based Enhanced IT Management System [PDF]

open access: yesInternational Journal of Engineering Science and Technology (IJEST), Vol. 4 No.03 March 2012, PP: 1199-1207, 2012
The integrated management of multi-providers equipments is a key asset for telecommunication operators or service providers when selecting the appropriate network and service management platform for their network. In this paper, we present an open and adaptable platform that support fault and configuration management for next-generation networks.
arxiv  

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