Results 121 to 130 of about 18,384,957 (344)

Managing Science

, 2011
Quality Assessment. Rector manificus , ladies and gentlemen, the answer that is given increasingly within the science system reads, “Let us count.” Let us count how many Euros have been acquired, how many publications are realized, and how many citations are generated. The higher the score, the better the researcher. However, it is not that simple.
openaire   +3 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Spatiotemporal patterns and drivers of ecosystem service interactions in karst regions: Insights for environmental protection and sustainability

iScience
Summary: Comprehending the interrelationships among ecosystem services (ESs) across temporal and spatial scales is fundamental for effective ES management.
Xuemao Zhang, Binggeng Xie, Junhan Li, Chuan Yuan, Kaichun Zhou, Jing Xie, Xiaofei Pang   +6 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Publishing Environmental Assessment and Management Science: Crossing the Hurdles. [PDF]

Bioscience, 2020
Efroymson RA, Peterson MJ.
europepmc   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

INTEGRATION PROCESS IN MANAGEMENT SCIENCE - THEORETICAL REVIEW [PDF]

Annals of the University of Petrosani: Economics, 2011
Complexity of phenomena found in the social, economic and environmental sphere of modern economic systems constitute one of factors in favor of attempts to apply examination approaches based on the analysis of the management integration phenomena in ...
IOAN CONSTANTIN DIMA, RENATA VOKOROKOSOVA, PIOTR PACHURA, MIHAELA SANDU   +3 more
doaj  

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Basics of inventory management (Part 4: The (s,S)-model) [PDF]

Inventory Models;management ...
Kok, A.G. de
core   +1 more source

Construction management research and the attempt to build a social science [PDF]

, 1998
The paper challenges the view that the major theoretical and methodological issues in the social sciences have been resolved and that positivism provides the only sound basis for research in construction.
Rooke, JA, Seymour, D
core   +2 more sources