Results 51 to 60 of about 6,565,603 (355)
ABSTRACT Background Patients with high‐risk neuroblastoma who either are refractory to induction chemotherapy or relapse following multi‐modal treatment have a dismal prognosis. Based on data from the BEACON trial, since 2021 the UK national guidelines recommend bevacizumab, irinotecan, and temozolomide (BIT) for patients with relapsed/refractory ...
Thomas J. Jackson +20 more
wiley +1 more source
Entropy techniques for robust management decision making in high-dimensional data
Entropy, a key measure of chaos or diversity, has recently found intriguing applications in the realm of management science. Traditional entropy-based approaches for data analysis, however, prove inadequate when dealing with high-dimensional datasets. In
Jan Kalina
doaj +1 more source
ABSTRACT Background Alveolar soft part sarcoma (ASPS) is a rare soft tissue sarcoma occurring most commonly in adolescence and young adulthood. Methods We present the clinical characteristics, treatments, and outcomes of patients with newly diagnosed ASPS enrolled on the Children's Oncology Group study ARST0332.
Jacquelyn N. Crane +11 more
wiley +1 more source
Accounting for Science: The Independence of Public Research in the New, Subterranean Administrative Law [PDF]
The White House Office of Management and Budget (OMB) is putting the final touches on a system designed to account for the science used by federal agencies in their administrative missions.
Hornstein, Donald T.
core +2 more sources
A Complexity Science Based Approach to Programme Risk Management [PDF]
Programme management has rapidly gained acceptance as a vehicle for achieving organisational strategic objectives and as a means of aligning projects with the overall strategy of the organisation.
Aritua, B., Bower, D.A., Smith, N.J.
core
ABSTRACT Background Parents of children treated for acute lymphoblastic leukemia (ALL) often experience significant caregiver burden and disruption to their well‐being. While parent quality of life (QoL) during treatment is well characterized, little is known about outcomes during early survivorship.
Sara Dal Pra +3 more
wiley +1 more source
YAWL: An open source Business Process Management System from science for science
YAWL (Yet Another Workflow Language) is an open source Business Process Management System, first released in 2003. YAWL grew out of a university research environment to become a unique system that has been deployed worldwide as a laboratory environment ...
Michael Adams +2 more
doaj +1 more source
The organization and management of the Virtual Astronomical Observatory [PDF]
The U.S. Virtual Astronomical Observatory (VAO; http://www.us-vao.org/) has been in operation since May 2010. Its goal is to enable new science through efficient integration of distributed multi-wavelength data.
Berriman, G. Bruce +4 more
core +2 more sources
Rapid Response to Trametinib Combined With Chemotherapy for Infant BRAF‐Fused Chiasmatic Glioma
ABSTRACT Infants, less than 1 year, with chiasmatic gliomas (ICG) present a major therapeutic challenge due to large tumor size, decreased vision, rapid progression, and poor response to vincristine/carboplatin chemotherapy. The majority have a BRAF fusion, which may respond to downstream MEK inhibitors but response time is slow. There are no safety or
Helen Toledano +7 more
wiley +1 more source
Future management needs of a "software-driven" science community
The work of astronomers is getting more complex and advanced as the progress of computer development occurs. With improved computing capabilities and increased data flow, more sophisticated software is required in order to interpret, and fully exploit ...
Moeller-Nilsson, Ole, Nilsson, Kim K.
core +1 more source

