Results 81 to 90 of about 17,203,168 (348)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

La ciencia gerencial (management science)

Revista Escuela de Administracion de Negocios, 1995
RESUMEN El siguiente ensayo, se presenta como inducción de una nueva gerencial en Colombia, ubicándose en la necesidad de modernizar y fortalecer los desarrollos de la ciencia gerencial en la enseñanza de la administración se ilustra con algunos ...
Jaime Sicard Ramírez
doaj   +2 more sources

A relação entre a Ciência da Informação e a Ciência da Administração

Transinformação
Este artigo discorre sobre a saga interdisciplinar entre a Ciência da Informação e a Ciência da Administração. O principal escopo dessa trama se concentra na informação, cujos atributos e propriedades se mesclam entre as duas Ciências.
Cláudio Augusto Alves, Emeide Nobrega Duarte   +1 more
doaj   +1 more source

Institutional Context of Pest Management Science in the Global South. [PDF]

Plants (Basel), 2023
Wyckhuys KAG, Hadi BAR.
europepmc   +1 more source

SDN management layer: design requirements and future direction [PDF]

, 2014
Computer networks are becoming more and more complex and difficult to manage. The research community has been expending a lot of efforts to come up with a general management paradigm that is able to hide the details of the physical infrastructure and ...
Matta, Ibrahim, Wang, Yuefeng
core   +2 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Virtual power plant for energy management: Science mapping approach. [PDF]

Heliyon, 2023
Zarate-Perez E, Grados J, Rubiños S, Solis-Tipian M, Cuzcano-Rivas A, Astocondor-Villar J, Grados-Espinoza H.   +6 more
europepmc   +1 more source

European Code Against Cancer, 5th edition – hormone replacement therapy, other common medical therapies and cancer

Molecular Oncology, EarlyView.
The 5th edition of the European Code Against Cancer (ECAC5) contains 14 recommendations on cancer prevention. Here, we update the cancer prevention recommendations regarding the use of hormone replacement therapy (HRT), which is positioned as recommendation number 13 of the ECAC5.
Mangesh A. Thorat, Marc Arbyn, David Baldwin, Xavier Castells, Solveig Hofvind, Urska Ivanus, Carlo Senore, Esther Toes‐Zoutendijk, Carlijn van der Aalst, Carlos Canelo‐Aybar, Fiorella Karina Fernández‐Sáenz, Ariadna Feliu, Hajo Zeeb, Andre L. Carvalho, Erica D'Souza, David Ritchie, Carolina Espina, Iris Lansdorp‐Vogelaar, Andrea DeCensi   +18 more
wiley   +1 more source

Project Management and Intellectual Property [PDF]

Recent approaches consider the knowledge as a determinant factor in the current economy, moving from the knowledge-based economy to the knowledge driving economy. (European Commission - Directorate-General for Enterprise 2004) In that context, along with
Ion NAFTANAILA, Mircea NEGRUTA
core  

Fostering open science practice through recognising and rewarding research data management and curation skills [PDF]

, 2016
In a bid to improve research integrity, drive innovation, increase knowledge and to maximize public investment, researchers are increasingly under pressure to work in a more open and transparent way.
Davidson, Joy
core   +1 more source