Results 111 to 120 of about 3,448,451 (296)

Editorial: Environmental DNA Innovations for Conservation

Frontiers in Ecology and Evolution, 2021
Matthew A. Barnes, Katy Klymus, Hiroki Yamanaka   +2 more
doaj   +1 more source

Safety and efficacy of glycopyrrolate oral solution for management of pathologic drooling in pediatric patients with cerebral palsy and other neurologic conditions

Therapeutics and Clinical Risk Management, 2012
Robert S Zeller1, Jennifer Davidson2, Hak-Myung Lee2, Paul F Cavanaugh21Texas Children's Hospital, Baylor College of Medicine, Houston, TX; 2Shionogi Inc, Florham Park, NJ, USABackground: The purpose of this study was to assess the safety and ...
Zeller RS, Davidson J, Lee HM, Cavanaugh PF   +3 more
doaj  

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

The business of process integration [PDF]

The paper describes the value of application integration and the place of business process management. It focuses on the duet BPM-SOA as the successful solution to build the adaptive enterprise of the near future.integration, ERP, enterprise applications,
Hurbean, Luminita
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Geo-spatial based cyclone shelter suitability assessment using analytical hierarchy process (AHP) in the coastal region of Bangladesh

Heliyon
The coastal district of Bangladesh is susceptible to cyclones, which cause significant damage to infrastructure, economy, and social structures every year.
Irteja Hasan, Md Omar Faruk, Zarin Tasnim Katha, Md Osman Goni, Md Shafiqul Islam, Tapas Ranjan Chakraborty, Sheikh Fahim Faysal Sowrav, Md Shakhawat Hossain   +7 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

INTEGRATED DOCUMENT MANAGEMENT SOLUTION FOR THE LOCAL GOVERNMENT [PDF]

Annals of the University of Oradea: Economic Science, 2013
In this paper we present system analysis and design elements for the integrated document management solution at local governing authorities in the rural areas.
Nistor Razvan, Muresan Ioana, Moca Mircea,   +3 more
doaj  

GRASS ROOTS FEDERAL LAND MANAGEMENT: IS THIS DEVOLUTION REALLY THE SOLUTION? [PDF]

Land Economics/Use,
Loomis, John B.
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source