Results 51 to 60 of about 32,493 (248)
Cancer‐Associated BCL‐2 Mutants Reveal Mechanisms Towards Venetoclax Resistance
Advanced Science, EarlyView.Venetoclax (VEN) resistance in chronic lymphocytic leukemia arises from diverse BCL2 mutations. We map mechanisms contributing to VEN resistance across common BCL‐2 variants. G101V and D103Y reduce drug binding and increase sequestration of pro‐apoptotic proteins. V156D blocks VEN allosterically.
Jonas Aufdermauer +9 more
wiley +1 more source
Training Management Decision Support System
Цифрова платформа: інформаційні технології в соціокультурній сфері, 2018 The purpose of the article is to study the processes of management training, review and description of the author's system of support for the managerial decisions adoption on personnel training, taking into account the rating assessment of training ...
Olha Tkachenko, Kostiantyn Tkachenko
doaj +1 more source
Intuition and managerial decision-making [PDF]
Human Affairs, 2017 Abstract The study examines new possibilities for recognising and understanding intuitive managerial decision-making, which is increasingly discussed in relation to the theory of management. Managers make decisions in organisations which have been undergoing transformation related to societal changes.
openaire +1 more source
Single‐Atom‐Enhanced Fully Inkjet‐Printed Electrochemical Sensor for Dopamine Detection
Advanced Science, EarlyView.Fully inkjet‐printed paper‐based dopamine sensors are fabricated using nitrogen‐doped graphene acid functionalized with copper single atoms. The copper sites uniquely enhance dopamine oxidation through strong molecular adsorption, as verified by electrochemical measurements and DFT calculations. The approach highlights the potential of single‐atom inks
Martin‐Alex Nalepa +11 more
wiley +1 more source
Advanced Science, EarlyView.Endothelial miR‐15a/16‐1 deletion promotes long‐term recovery after traumatic brain injury by restoring SYNE1 expression. Enhanced endothelial SYNE1 preserves vascular integrity, protects white and gray matter, and improves neurological function. The endothelial miR‐15a/16‐1–SYNE1 axis emerges as a key regulator of neurovascular repair and a potential ...
Shun Li +17 more
wiley +1 more source
The Impact of Managerial Decision-Making on Employee Motivation in Manufacturing Companies
Journal of Competitiveness, 2020 In terms of competition, manufacturing companies are focusing more and more on employee performance as well as motivation, the latter of which seems to be a prerequisite for the long-term performance of employees and thus the sustainable success of the ...
Jozef Habanik +2 more
doaj +1 more source
HOLISMIN MANAGERIAL DECISION MAKING
Öneri Dergisi, 2020 The paper mirrors the rising maturity of systems thought and Systems language in managerial decision-makiiig or problem management. It is based upon the assumption that building blocks of reality are not parts but ivholes—systems in which ill-structured and systemic problems having social and behavioral aspects and interdependeiicy cannot be worked out
openaire +3 more sources
Advanced Science, EarlyView.The protein aggregates and gene expression in the middle temporal gyrus (MTG) and somatosensory cortex (SOM) of the postmortem brains of 13 Alzheimer's disease patients were studied in detail, revealing that small hyperphosphorylated tau aggregates increase with Braak stage driven by microglial inflammation.
Elizabeth A. English +9 more
wiley +1 more source
CRISPR and Gene Augmentation Rescue Trabecular Meshwork Dysfunction in iPSC Models of Lowe Syndrome
Advanced Science, EarlyView.By modeling Lowe syndrome using patient‐derived iPSCs, this study establishes a human disease model that faithfully recapitulates OCRL deficiency‐associated ciliary and cytoskeletal defects. The model enables evaluation of both mutation‐agnostic DNA augmentation and CRISPR‐mediated mutation correction strategies, both of which restore OCRL function and
Siyu Chen +11 more
wiley +1 more source
Advanced Science, EarlyView.Tau populations with different aggregation states associate with distinct sets of proteins in the Alzheimer's disease brain. Proteomic discovery combined with single‐molecule analysis in neurons reveals dynamic associations involving proteostasis, metabolism and RNA biology.
Dorothea Böken +8 more
wiley +1 more source