Results 51 to 60 of about 32,511 (248)

Training Management Decision Support System

open access: yesЦифрова платформа: інформаційні технології в соціокультурній сфері, 2018
The purpose of the article is to study the processes of management training, review and description of the author's system of support for the managerial decisions adoption on personnel training, taking into account the rating assessment of training ...
Olha Tkachenko, Kostiantyn Tkachenko
doaj   +1 more source

Managerial Decision Making Under Uncertainty [PDF]

open access: yesJournal of Sports Economics, 2014
We consider managerial decision making by examining the impact of decisions taken by cricket captains on Twenty20 International (T20I) match outcomes. In particular, we examine whether pressure from external commentators is associated with suboptimal decision making by captains. Using data from over 300 T20I matches, we find little evidence that either
Sacheti A, Gregory-Smith I, Paton D
openaire   +3 more sources

Single‐Atom‐Enhanced Fully Inkjet‐Printed Electrochemical Sensor for Dopamine Detection

open access: yesAdvanced Science, EarlyView.
Fully inkjet‐printed paper‐based dopamine sensors are fabricated using nitrogen‐doped graphene acid functionalized with copper single atoms. The copper sites uniquely enhance dopamine oxidation through strong molecular adsorption, as verified by electrochemical measurements and DFT calculations. The approach highlights the potential of single‐atom inks
Martin‐Alex Nalepa   +11 more
wiley   +1 more source

Endothelial miR‐15a/16‐1 Regulation of SYNE1 Mediates Structural and Functional Recovery after Traumatic Brain Injury

open access: yesAdvanced Science, EarlyView.
Endothelial miR‐15a/16‐1 deletion promotes long‐term recovery after traumatic brain injury by restoring SYNE1 expression. Enhanced endothelial SYNE1 preserves vascular integrity, protects white and gray matter, and improves neurological function. The endothelial miR‐15a/16‐1–SYNE1 axis emerges as a key regulator of neurovascular repair and a potential ...
Shun Li   +17 more
wiley   +1 more source

The Impact of Managerial Decision-Making on Employee Motivation in Manufacturing Companies

open access: yesJournal of Competitiveness, 2020
In terms of competition, manufacturing companies are focusing more and more on employee performance as well as motivation, the latter of which seems to be a prerequisite for the long-term performance of employees and thus the sustainable success of the ...
Jozef Habanik   +2 more
doaj   +1 more source

HOLISMIN MANAGERIAL DECISION MAKING

open access: yesÖneri Dergisi, 2020
The paper mirrors the rising maturity of systems thought and Systems language in managerial decision-makiiig or problem management. It is based upon the assumption that building blocks of reality are not parts but ivholes—systems in which ill-structured and systemic problems having social and behavioral aspects and interdependeiicy cannot be worked out
openaire   +3 more sources

Tau Aggregate Imaging and Transcriptomics of Alzheimer's Disease Brain at Different Stages of Disease

open access: yesAdvanced Science, EarlyView.
The protein aggregates and gene expression in the middle temporal gyrus (MTG) and somatosensory cortex (SOM) of the postmortem brains of 13 Alzheimer's disease patients were studied in detail, revealing that small hyperphosphorylated tau aggregates increase with Braak stage driven by microglial inflammation.
Elizabeth A. English   +9 more
wiley   +1 more source

CRISPR and Gene Augmentation Rescue Trabecular Meshwork Dysfunction in iPSC Models of Lowe Syndrome

open access: yesAdvanced Science, EarlyView.
By modeling Lowe syndrome using patient‐derived iPSCs, this study establishes a human disease model that faithfully recapitulates OCRL deficiency‐associated ciliary and cytoskeletal defects. The model enables evaluation of both mutation‐agnostic DNA augmentation and CRISPR‐mediated mutation correction strategies, both of which restore OCRL function and
Siyu Chen   +11 more
wiley   +1 more source

Temporal Trajectories of the Tau Aggregate Interactome Reveal Stage‐Specific Vulnerabilities in Alzheimer's Disease

open access: yesAdvanced Science, EarlyView.
Tau populations with different aggregation states associate with distinct sets of proteins in the Alzheimer's disease brain. Proteomic discovery combined with single‐molecule analysis in neurons reveals dynamic associations involving proteostasis, metabolism and RNA biology.
Dorothea Böken   +8 more
wiley   +1 more source

Zinc Fingers as Programmable Metalloprotein Scaffolds for Altering Pathogenic Biomolecular Phase Transitions

open access: yesAdvanced Science, EarlyView.
Modular zinc finger (ZF) metalloproteins function as programmable biomolecular scaffolds that modulate pathogenic amyloid assembly. Through direct protein–protein interactions, ZF arrays alter amyloid phase behavior and redirect β‐sheet fibrillization toward nontoxic aggregates.
Seongmin Park   +16 more
wiley   +1 more source

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