Results 191 to 200 of about 287,737 (266)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

open access: yesFEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

"I can't just talk it. I have to live it": the roles, needs, and recruitment of recovery home house managers. [PDF]

open access: yesFront Public Health
Zoschke IN   +6 more
europepmc   +1 more source

Redesigning the model for providing primary healthcare in Iran: a grounded theory study in rural settings. [PDF]

open access: yesPrim Health Care Res Dev
Fani F   +7 more
europepmc   +1 more source

Designing and Psychometric Evaluation of Professional Competency Assessment Tools in Educating Accident and Emergency Managers. [PDF]

open access: yesJ Adv Med Educ Prof
Moradi HA   +5 more
europepmc   +1 more source

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