Results 251 to 260 of about 1,667,290 (353)

Accommodation of Biodiversity in Swedish Municipalities. A National Survey. [PDF]

Environ Manage
Christoffersen L, Englund JE, Randrup T.
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Effects of Perceived Management Care and Job Embeddedness on Organizational Commitment Among Registered Clinical Nurses: A Latent Profile Analysis. [PDF]

J Nurs Res
Gong Z, Chen D, Huang Y, Wu Y, Jin H.
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

"I can't just talk it. I have to live it": the roles, needs, and recruitment of recovery home house managers. [PDF]

Front Public Health
Zoschke IN, Gallardo KR, Stewart HLN, Rodriguez SA, Gillespie D, McCurdy SA, Wilkerson JM.   +6 more
europepmc   +1 more source

Designing and Psychometric Evaluation of Professional Competency Assessment Tools in Educating Accident and Emergency Managers. [PDF]

J Adv Med Educ Prof
Moradi HA, Rambod M, Rezaee R, Ahmadi Marzaleh M, Peyravi M, Amini M.   +5 more
europepmc   +1 more source

Measuring organisational readiness for health system change in South Africa using the European Foundation for Quality Management Excellence Model (EFQM). [PDF]

PLOS Glob Public Health
Masike MA, Mahomed OH.
europepmc   +1 more source

Correction to "Obstetric Emergency Preparedness in Arkansas Emergency Departments". [PDF]

J Am Coll Emerg Physicians Open
europepmc   +1 more source

Acceptance of Electronic Medical Records Among Practitioner Nurses and Nurse Managers Using the UTAUT Framework in Hospital Settings: A Scoping Review. [PDF]

J Multidiscip Healthc
Liana Y, Agustina HR, Yudianto K.
europepmc   +1 more source