Results 231 to 240 of about 599,668 (298)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

The ethicality of mandatory COVID-19 vaccinations in Uganda: a qualitative study. [PDF]

BMC Med Ethics
Nameri S, Nakwagala F, Barugahare J.
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Implementation of a prospective neurosurgical complication registry in routine clinical practice. [PDF]

Acta Neurochir (Wien)
Grimmer A, Geley-Eder KM, Böhm P, Seiter V, Atli B, Hauser A, Aufschnaiter-Hiessböck K, Rossmann T, Horner E, Gmeiner M, Giretzlehner M, Gruber A, Gollwitzer M.   +12 more
europepmc   +1 more source

Précis of <i>Inducing Immunity? Justifying Immunization Policies in Times of Vaccine Hesitancy</i>  ¹. [PDF]

Public Health Ethics
Pierik R, Verweij M.
europepmc   +1 more source

Influenza vaccine uptake among healthcare workers in GCC countries: a narrative review of enablers and barriers. [PDF]

Front Public Health
Ali SA, Ille S, Muttappallymyalil J, Sreedharan J, Ahmed M.   +4 more
europepmc   +1 more source

Implications of Potential US FDA Approval of Psychedelics or Psychedelic-Adjacents Such as Ibogaine for Pharmacy in Japan. [PDF]

Cureus
Raffa RB.
europepmc   +1 more source

Preferences for training on mandatory reporting of intimate partner violence among healthcare professionals: a Norwegian cross-sectional study. [PDF]

Front Public Health
Pilskog VK, Besley JC, Brevik TB.
europepmc   +1 more source