Results 61 to 70 of about 35,398 (275)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

The Willingness toward Vaccination: A Focus on Non-Mandatory Vaccinations

Vaccines, 2023
The Special Issue “The Willingness toward Vaccination: A Focus on Non-mandatory Vaccinations”, published in the journal Vaccines, has the main aim of gathering more data on vaccine hesitancy and the willingness of individuals to receive vaccinations, particularly in the context of non-mandatory vaccines.
Angelo Capodici, Francesco Sanmarchi, Nicole Bonaccorso, Claudio Costantino, Elisa Maietti   +4 more
openaire   +6 more sources

Mandatory COVID-19 vaccination for healthcare workers: A discussion paper

, 2022
BACKGROUND: The devastating effects of COVID-19 sparked debates among professionals in the fields of health, law, and bioethics regarding policies on mandatory vaccination for healthcare workers.
Montayre, Jed, Montayre, Jed (R20033), Maneze, Della, Maneze, Della (R19226), Ramjan, Lucie M. (R13951), Ramjan, Lucie, Salamonson, Yenna, Salamonson, Yenna (R8521), Grollman, Maxwell   +8 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Knowledge, attitudes and beliefs towards compulsory vaccination: a systematic review

Human Vaccines & Immunotherapeutics, 2019
Currently, many countries are dealing with groups refusing available recommended vaccinations. Despite several studies having demonstrated the efficacy of mandatory vaccinations in ensuring herd immunity, opposition is widespread.
MR Gualano, E Olivero, G Voglino, M Corezzi, P Rossello, C Vicentini, F Bert, R Siliquini   +7 more
doaj   +1 more source

Ethics of Vaccination: Mandatory vaccination

, 2022
V človeški zgodovini so bile nalezljive bolezni in epidemični izbruhi glavni vzroki smrti. Za omejitev širjenja nalezljive bolezni je potrebno doseči kolektivno imunost, ki pa jo danes lahko, po zaslugi moderne medicine, hitreje dosežemo s cepljenjem ...
Junkar, Klara
core  

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

To vaccinate or not to vaccinate:

Stellenbosch Theological Journal, 2022
Faith communities are challenged during the COVID-19 pandemic to urge their members to take a decision to vaccinate or not to vaccinate. The relationship between religion and medical sciences, especially with regard to vaccination, has not always complemented one another, but there is general agreement amongst religions that vaccination is acceptable ...
openaire   +2 more sources