Results 141 to 150 of about 783,178 (384)

Manganese promotes the aggregation and prion-like cell-to-cell exosomal transmission of α-synuclein

Science Signaling, 2019
Manganese exposure promotes α-synuclein propagation, neuroinflammation, and neurodegeneration. Manganese in Parkinson’s disease Manganese is an essential mineral, but chronic exposure to high amounts of it, such as is experienced by welders, is ...
Dilshan S. Harischandra, Dharmin Rokad, Matthew L. Neal, Shivani Ghaisas, Sireesha Manne, Souvarish Sarkar, Nikhil Panicker, G. Zenitsky, Huajun Jin, M. Lewis, Xuemei Huang, V. Anantharam, A. Kanthasamy, A. Kanthasamy   +13 more
semanticscholar   +1 more source

Hip morphology‐based osteoarthritis risk prediction models: development and external validation using individual participant data from the World COACH Consortium

Arthritis Care &Research, Accepted Article.
Objectives This study aims to develop hip morphology‐based radiographic hip osteoarthritis (RHOA) risk prediction models and investigates the added predictive value of hip morphology measurements and the generalizability to different populations. Methods We combined data from nine prospective cohort studies participating in the World COACH consortium ...
Myrthe A. van den Berg, Fleur Boel, Michiel M.A. van Buuren, Noortje S. Riedstra, Jinchi Tang, Harbeer Ahedi, Nigel K. Arden, Sita M.A. Bierma‐Zeinstra, Cindy G. Boer, Flavia M. Cicuttini, Timothy F. Cootes, David T. Felson, Willem Paul Gielis, Joshua Heerey, Graeme Jones, Stefan Kluzek, Nancy E. Lane, Claudia Lindner, Joyce B.J. van Meurs, Andrea Mosler, Amanda E. Nelson, Michael C. Nevitt, Edwin H. Oei, Jos Runhaar, Harrie Weinans, Jesse H. Krijthe, Rintje Agricola   +26 more
wiley   +1 more source

Manganese Suppresses the Haploinsufficiency of Heterozygous trpy1Δ/TRPY1 Saccharomyces cerevisiae Cells and Stimulates the TRPY1-Dependent Release of Vacuolar Ca²⁺ under H₂O₂ Stress

Cells, 2019
Transient potential receptor (TRP) channels are conserved cation channels found in most eukaryotes, known to sense a variety of chemical, thermal or mechanical stimuli.
Lavinia L. Ruta, Ioana Nicolau, Claudia V. Popa, Ileana C. Farcasanu   +3 more
doaj   +1 more source

Prevalence, determinants and outcomes of low disease activity and remission attainment in SLE patients with clinically active disease

Arthritis Care &Research, Accepted Article.
Objectives This study aimed to identify the frequency and determinants of Lupus Low Disease Activity State (LLDAS) and Definition of Remission in SLE (DORIS‐remission) attainment in systemic lupus erythematosus (SLE) patients with clinically active disease, and the frequency and determinants of flare and damage accrual after target attainment.
Yanjie Hao, Dylan Hansen, Rangi Kandane‐Rathnayake, Worawit Louthrenoo, Yi‐Hsing Chen, Jiacai Cho, Aisha Lateef, Laniyati Hamijoyo, Shue Fen Luo, Yeong‐Jian Jan Wu, Sandra Navarra, Leonid Zamora, Zhanguo Li, Sargunan Sockalingam, Yasuhiro Katsumata, Masayoshi Harigai, Zhuoli Zhang, Madelynn Chan, Jun Kikuchi, Tsutomu Takeuchi, Sang‐Cheol Bae, Fiona Goldblatt, Sean O'Neill, Kristine (Pek Ling) Ng, Annie Law, BMDB Basnayake, Nicola Tugnet, Sunil Kumar, Cherica Tee, Michael Tee, Naoaki Ohkubo, Yoshiya Tanaka, Shirley Chan, CS Lau, Vera Golder, Alberta Hoi, Shereen Oon, Eric Morand, Mandana Nikpour, for the Asia Pacific Lupus Collaboration   +39 more
wiley   +1 more source

Manganese activates NLRP3 inflammasome signaling and propagates exosomal release of ASC in microglial cells

Science Signaling, 2019
Exosomes containing the adaptor ASC spread NLRP3 inflammasome activation between cells after manganese exposure. Exosomes transfer inflammasome activation Chronic occupational exposure to manganese is associated with the development of Parkinson’s ...
Souvarish Sarkar, Dharmin Rokad, Emir Malovic, Jie Luo, Dilshan S. Harischandra, Huajun Jin, V. Anantharam, Xuemei Huang, M. Lewis, A. Kanthasamy, A. Kanthasamy   +10 more
semanticscholar   +1 more source

Neurological outcomes associated with low-level manganese exposure in an inception cohort of asymptomatic welding trainees

Scandinavian Journal of Work, Environment & Health, 2015
OBJECTIVE: Long-term, high-level exposure to manganese (Mn) is associated with impaired central nervous system (CNS) function. We quantitatively explored relations between low-level Mn exposure and selected neurological outcomes in a longitudinal ...
Marissa G Baker, Susan R Criswell, Brad A Racette, Christopher D Simpson, Lianne Sheppard, Harvey Checkoway, Noah S Seixas   +6 more
doaj   +1 more source

Foliar‐applied manganese and phosphorus in deficient barley: Linking absorption pathways and leaf nutrient status

, 2022
Maja Arsic, Daniel P. Persson, Jan K. Schjøerring, Lisbeth Garbrecht Thygesen, Enzo Lombi, Casey L. Doolette, Steen Husted   +6 more
openalex   +1 more source

Response to allopurinol and febuxostat according to the fractional excretion of urate in men with gout

Arthritis Care &Research, Accepted Article.
Background Body mass index (BMI), glomerular filtration rate (GFR), and pretreatment urate levels have been reported to influence the urate‐lowering response to allopurinol. We investigated whether the fractional excretion of urate (FEUA) also modulates this response and relates to oxypurinol concentrations. We further evaluated its potential influence
Pascal Richette, Anouk Walter‐Petrich, Quang Dinh Nguyen, Matthieu Resche‐Rigon, Quang Huy Dinh Nguyen, Minh Duc Do, Thao Phuong Mai, Tuan Duc Nguyen, Fernando Perez‐Ruiz, Emmanuel Letavernier, Tristan Pascart, Augustin Latourte, Hang Korng Ea, Thomas Bardin   +13 more
wiley   +1 more source

Maternal blood manganese level and birth weight: a MOCEH birth cohort study [PDF]

, 2014
Jin Hee Eum, Hae‐Kwan Cheong, Eun Hee Ha, Mina Ha, Yangho Kim, Yun Chul Hong, Hyesook Park, Namsoo Chang   +7 more
openalex   +1 more source

Simultaneous Sequestration of Co2+ and Mn2+ by Fungal Manganese Oxide through Asbolane Formation [PDF]

, 2022
Miku Aoshima, Yukinori Tani, Rina Fujita, Kazuya Tanaka, Naoyuki Miyata, Kazuhiro Umezawa   +5 more
openalex   +1 more source