Results 141 to 150 of about 214,218 (278)

Understanding factors that could influence feasibility and acceptability of brief CAT for adults who self‐harm: A qualitative exploration using the theoretical framework of acceptability

open access: yesPsychology and Psychotherapy: Theory, Research and Practice, EarlyView.
Abstract Introduction Self‐harm in adults is a complex and highly prevalent problem. The Relational Approach to Treating Self‐Harm (RELATE, ISRCTN code: ISRCTN75661422) trial investigated the feasibility, acceptability and safety of 8‐session cognitive analytic therapy (CAT) for self‐harm, compared with treatment as usual.
Isabel Adeyemi   +9 more
wiley   +1 more source

Immune involvement in neuropsychiatric disorders: Insights from single‐cell transcriptomic studies

open access: yesPsychiatry and Clinical Neurosciences, EarlyView.
Neuropsychiatric disorders pose profound challenges to both research and treatment, largely due to their clinical heterogeneity and the limited understanding of their underlying biological mechanisms. While bulk RNA sequencing (bulk RNA‐seq) has been widely used to study gene expression, it cannot resolve cell‐type‐specific signals or detect rare ...
Tsutomu Takeda   +4 more
wiley   +1 more source

The development of positron emission tomography (PET) tracer for glutamate AMPA receptors and its application to human biology and clinics

open access: yesPsychiatry and Clinical Neurosciences, EarlyView.
Psychiatric and neurological disorders severely compromised patients' quality of life. Despite their urgent needs, the development of diagnostics and therapeutics based on the biological basis has made only little progress. This is due to limited evidence on the biological basis of these disorders in humans. Synapses are fundamental structural units of
Mai Hatano, Hiroki Abe, Takuya Takahashi
wiley   +1 more source

Functional and structural connectivity of thalamic subnuclei in major depressive disorder at 7 Tesla

open access: yesPsychiatry and Clinical Neurosciences, EarlyView.
Aims Major depressive disorder (MDD) is widely considered to be a mood disorder characterized by altered connectivity. The thalamus plays an important role in MDD by connecting large areas of the brain. Here, we explored thalamic connectivity in MDD at the subnuclear level using ultra‐high‐field MRI.
Weijian Liu   +10 more
wiley   +1 more source

Anxiety and Evidence

open access: yesPhilosophical Issues, EarlyView.
ABSTRACT When does an agent possess a proposition P as evidence? According to Timothy Williamson, the answer is when, and only when, they know that P. Call this view E = K. In this article, I point out an unwanted consequence of E = K, which is that people who suffer from anxiety have impoverished empirical evidence due to their anxiety.
Rhys Borchert
wiley   +1 more source

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