Results 101 to 110 of about 23,024 (166)

Immune Dysregulation in Bipolar Disorder: The Role of IL-27 and EBI3

BJPsych Open
Aims: Bipolar disorder (BD) is a severe psychiatric illness characterized by alternating depressive and manic episodes. The exact cause of BD remains unclear, but inflammatory and immunological processes are believed to play a significant role in its ...
Golnaz Sheykhnazari, Maliheh Ziaee, Ezinne Ijeoma Onuba, Najmeh Shahini, Yaser Bagheri   +4 more
doaj   +1 more source

Antidepressant-induced Dopamine Receptor Dysregulation: A Valid Animal Model of Manic-Depressive Illness. [PDF]

Curr Neuropharmacol, 2017
Demontis F, Serra F, Serra G.
europepmc   +1 more source

HLA genotype testing for carbamazepine, oxcarbazepine and eslicarbazepine: A guideline developed by the UK Centre of Excellence in Regulatory Science and Innovation in Pharmacogenomics (CERSI‐PGx)

British Journal of Clinical Pharmacology, Volume 92, Issue 7, Page 1957-1976, July 2026.
Carbamazepine is licensed in the United Kingdom for the treatment of epilepsy, bipolar disorder and trigeminal neuralgia. The related compounds oxcarbazepine and eslicarbazepine are licensed for the treatment of epilepsy. These drugs can cause immune‐mediated hypersensitivity reactions, which typically affect the skin, and can be of variable severity ...
Lucy Galloway, Cinzia Dello Russo, Nicholas Bass, Elvira Bramon, Helen Cross, Natalie Curley, Sarah Curran, Helen Davies, Jana De Villiers, William Evans, Bernhard Frank, Alice Groves, Judith Hayward, Jon Higham, Dyfrig A. Hughes, Shwe Sin Kyaw, Anthony G. Marson, Ailsa McLellan, Seth Mensah, Francis O'Neill, Jane Sargison, Sanjay M. Sisodiya, Jill Swan, Joanna M. Zakrewska, Munir Pirmohamed   +24 more
wiley   +1 more source

Radiomic Signature of the Substantia Nigra on Neuromelanin‐Sensitive MRI Distinguishes Bipolar II Disorder From Unipolar Depression

Brain and Behavior, Volume 16, Issue 7, July 2026.
This radiomics pipeline employed neuromelanin‐sensitive MRI to extract 2,854 features from bilateral nigral ROIs in BD‐II, UD, and HC. After Z‐score normalization, ICC (≥0.75) retention, ANOVA‐FDR (P<0.05) filtering, and collinearity removal (excluding feature pairs with |r| >0.8), LASSO regression selected 7 optimal features.
Xinping Kuai, Dandan Shao, Shengyu Wang, Fangsong Zhang, Suzhen Zhang, Xuexue Wang, Jinhong Wang   +6 more
wiley   +1 more source

Brexpiprazole and Quetiapine Use During Pregnancy and Lactation: A Case Report

Clinical Case Reports, Volume 14, Issue 7, July 2026.
ABSTRACT Brexpiprazole, used off‐label in combination with quetiapine, may be a treatment option during pregnancy and breastfeeding when the risk of maternal relapse outweighs potential fetal or infant risks. This case describes perinatal use of polypharmacy without apparent adverse maternal or infant outcomes, underscoring the need for individualized,
Awateif Alsupiany
wiley   +1 more source

Pathways to Mental Health: Exploring the Relationships Among Neighborhood Hostility, Crime, Built Environment, and Perceived Safety

Journal of Community Psychology, Volume 54, Issue 5, July 2026.
ABSTRACT Neighborhood crime‐related stressors and the built environment are important determinants of mental health, yet research on the pathways through which they affect individuals remains limited. This study draws on structural equation modeling and high‐quality measures to test the pathways linking a novel measure of neighborhood‐level hostility ...
Paul Rodrigues, Carolyn Côté‐Lussier
wiley   +1 more source

Individualised Music Playlist Based on the Iso‐Principle for De‐Escalating Agitation in Older People With Dementia: Protocol for a RCT

Nursing Open, Volume 13, Issue 7, July 2026.
ABSTRACT Aim To evaluate the efficacy of an individualised music playlist composed of preferred music genres sequenced using the Iso‐Principle (InMP) for immediate de‐escalation of agitation in dementia, compared with preferred music (PM) and treatment as usual (TAU). Design A multi‐centre, three‐arm randomised controlled trial.
Daphne Sze Ki Cheung, Jodie Hau Yi Tse, Ken Hok Man Ho, Jennifer Macritchie, Claudia Kam Yuk Lai, Kathleen Buckwalter, Shanshan Wang, Paul Hong Lee, Daniel Bressington, Angel Hiu Tung Chan, Grace Wing Ka Ho   +10 more
wiley   +1 more source

Advancing Dimensional Models of Psychopathology in Cancer: Insights From Applying the Hierarchical Taxonomy of Psychopathology (HiTOP)

Psycho-Oncology, Volume 35, Issue 7, July 2026.
ABSTRACT Objective Cancer survivors, defined as those living with or beyond a cancer diagnosis, experience more than double the prevalence of psychopathology when compared to the general population. Categorical diagnostic systems, such as the Diagnostic and Statistical Manual of Mental Disorders (DSM), remain dominant in psycho‐oncology despite ...
Darren Haywood, Jai Carmichael, Miriam K. Forbes, Roman Kotov, Robert F. Krueger, Aidan G. C. Wright, Susan L. Rossell, David Castle, Wendy Lam, Maryam Lustberg, Colin E. Vize, Anna Ugalde, Phyllis Butow, Nicolas H. Hart   +13 more
wiley   +1 more source

Pineal Gland Volume, Sleep Quality, and Psychiatric Disorders: A Systematic Review and Meta‐Analysis

Acta Psychiatrica Scandinavica, Volume 154, Issue 1, Page 36-49, July 2026.
ABSTRACT Introduction Disturbances in sleep and circadian rhythms are features of several psychiatric disorders. The pineal gland regulates these rhythms via melatonin, with pineal gland volume (PGV) serving as a structural proxy. We conducted a meta‐analysis to synthesize evidence on differences in PGV between patients with psychiatric disorders and ...
Sophie Bolwig, Kristian H. R. Jensen
wiley   +1 more source

Trajectories of Suicidal Risk Impact Mood Regulation Differently in Patients With a Diagnosis of Bipolar Disorder

Acta Psychiatrica Scandinavica, Volume 154, Issue 1, Page 60-73, July 2026.
ABSTRACT Background Bipolar disorder (BD) carries a suicide risk 20 times higher than the general population, with up to 60% of patients attempting suicide. Current interventions have failed to reduce its incidence; static factors have shown limited predictive utility.
Abigail Ortiz, Ramzi Halabi, Daniel Blumberger, Christina Gonzalez‐Torres, Arend Hintze, Muhammad I. Husain, Mirkamal Tolend, Juveria Zaheer, Martin Alda, Benoit H. Mulsant   +9 more
wiley   +1 more source