Results 141 to 150 of about 238,379 (310)
Stateness and quality of democracy in Paraguay Estatalidad y calidad de la democracia en Paraguay
América Latina Hoy, 2012 Taking into account the fact that in all existing indices of the quality of democracy Paraguay fares rather poorly, the author explores how «stateness» accounts for that poor performance.
Diego ABENTE BRUN
doaj
Stop the Integration Principle? [PDF]
, 2009 Lord Slynn of Hadley is probably not primarily known as an environmental lawyer. His contributions to the development of European environmental law are, however, considerable. On May 24, 1988, Slynn delivered his famous opinion in the so-called Danish
Jans, Prof. Dr. Jan H.
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Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Adrenal insufficiency presenting as hypercalcemia and acute kidney injury
International Medical Case Reports Journal, 2016 Seung Won Ahn,1 Tong Yoon Kim,1 Sangmin Lee,1 Jeong Yeon Jeong,1 Hojoon Shim,1 Yu min Han,1 Kyu Eun Choi,1 Seok Joon Shin,1,2 Hye Eun Yoon,1,2 1Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, 2Division of ...
Ahn SW +8 more
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The abject and the vulnerable: the twain shall meet: reflections on disability in the moral economy [PDF]
, 2019 Hughes, Bill
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Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Pathological pregnancy and psychological symptoms in women [Patološka trudnoća i psihički simptomi u žena] [PDF]
, 2012 Pregnancy is followed by many physiologic, organic and psychological changes and disorders, which can become more serious in pregnancy followed by complications, especially in women with pathological conditions during pregnancy. The purpose of this study
Bjelanović, Vedran +5 more
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Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source