Results 1 to 10 of about 392,644 (203)

An itchy rash and muscle weakness [PDF]

Clinical Case Reports, 2021
Dermatomyositis is a rare disease affecting primarily skin and muscles and is associated with malignancies, especially in at‐risk patients. Clinical presentations vary widely but proximal muscle weakness and typical skin findings should prompt ...
Brian L. Risavi, Justin Puller, Kristin Juhasz   +2 more
doaj   +3 more sources

Muscle Weakness

Journal of Investigative Medicine High Impact Case Reports, 2017
Marked ligamentous hyperlaxity and muscle weakness/wasting associated with awkward gait are the main deficits confused with the diagnosis of myopathy.
Ali Al Kaissi MD, MSc, Sergey Ryabykh MD, Polina Ochirova MD, Vladimir Kenis MD, Jochen G. Hofstätter MD, Franz Grill MD, Rudolf Ganger MD, PhD, Susanne Gerit Kircher MD, MSc   +7 more
doaj   +3 more sources

Identifying Susceptibility Genes and Shared Genetic Architecture for Longevity and Muscle Weakness [PDF]

Journal of Cachexia, Sarcopenia and Muscle
Background Longevity and muscle strength are heritable traits, and age‐related muscle weakness is a major contributor to disability in older adults. However, the susceptibility genes and shared genetic mechanisms underlying lifespan and sarcopenia remain
Yilong Lin, Yun Zhang, Shengjie Lin, Songsong Wang, Zhiqiang Que, Yue Zhang, Jing She, Ruidan Zhao, Jiawei Chen, Anqi Qiu, Shinan Wu, Ruiqin Yang, Liyi Zhang, Qingmo Yang   +13 more
doaj   +2 more sources

Excess TGF-β mediates muscle weakness associated with bone metastases in mice [PDF]

Nature Medicine, 2015
Cancer-associated muscle weakness is a poorly understood phenomenon, and there is no effective treatment. Here we find that seven different mouse models of human osteolytic bone metastases-representing breast, lung and prostate cancers, as well as ...
David L Waning, Steven Reiken, Wenjun Xie   +2 more
exaly   +4 more sources

Muscle Weakness in Rheumatoid Arthritis: The Role of Ca2+ and Free Radical Signaling

EBioMedicine, 2017
In addition to the primary symptoms arising from inflammatory processes in the joints, muscle weakness is commonly reported by patients with rheumatoid arthritis (RA).
Takashi Yamada, Maarten M. Steinz, Ellinor Kenne, Johanna T. Lanner   +3 more
doaj   +3 more sources

Muscle weakness with a hidden cause. [PDF]

BMJ Case Rep
Idiopathic inflammatory myopathies (IIM) represent a diverse group of systemic autoimmune disorders characterised by skeletal muscle weakness with variable clinical manifestations. Dermatomyositis (DM) is a heterogeneous IIM and is associated with progressive muscle weakness, with characteristic skin features, and with an increased risk ...
Mueller SM, Schaefer JE, Hortobagyi T, Thurnheer R.   +3 more
europepmc   +3 more sources

The impact of lipid-rich nutrition on ketogenesis and muscle weakness in sepsis [PDF]

Intensive Care Medicine Experimental
Background Administration of ketone bodies attenuated the severity of sepsis-induced muscle weakness in preclinical studies. Whether lipid-rich emulsions may likewise mitigate such muscle weakness by stimulating the endogenous ketogenic capacity remains ...
Caroline Lauwers, Jan Gunst, Soraya El Dawy, Sarah Derde, Lies Pauwels, Inge Derese, Sarah Vander Perre, Greet Van den Berghe, Michael P. Casaer, Lies Langouche   +9 more
doaj   +2 more sources

Mitochondrial-targeted plastoquinone therapy prevents early onset muscle weakness that occurs before atrophy during ovarian cancer [PDF]

Molecular Metabolism
Objective: Muscle loss with cancer causes weakness, worsens quality of life, and predicts reduced overall survival rates. Recently, muscle weakness was identified during early-stage cancer before atrophy develops. This discovery indicates that mechanisms
Luca J. Delfinis, Shahrzad Khajehzadehshoushtar, Luke D. Flewwelling, Nathaniel J. Andrews, Madison C. Garibotti, Shivam Gandhi, Aditya N. Brahmbhatt, Brooke A. Morris, Bianca Garlisi, Sylvia Lauks, Caroline Aitken, Leslie Ogilvie, Stavroula Tsitkanou, Jeremy A. Simpson, Nicholas P. Greene, Arthur J. Cheng, Jim Petrik, Christopher G.R. Perry   +17 more
doaj   +2 more sources

Sodium bicarbonate for the treatment of severe metabolic acidosis with moderate or severe acute kidney injury in the critically ill: protocol for a randomised clinical trial (BICARICU-2)

BMJ Open, 2023
Introduction When both severe metabolic acidemia (pH equal or less than 7.20; PaCO2 equal or less than 45 mm Hg and bicarbonate concentration equal or less than of 20 mmol/L) and moderate-to-severe acute kidney injury are observed, day 28 mortality is ...
Samir Jaber, Nicolas Molinari, Boris Jung, Helena Huguet   +3 more
doaj   +1 more source

A case of weak muscles [PDF]

Annals of the Rheumatic Diseases, 2002
Gut involvement in inflammatory myositis is rare but causes significant morbidity and mortality.A case of eosinophilic gastroenteritis and polymyositis occurring in the same patient is described. The interface of visceral and striated muscle involvement is discussed.
N, Sofat, M, Pitcher, A, Price, J N, El-Jabbour, C S, Higgens   +4 more
openaire   +2 more sources