Sclerostin inhibition alleviates breast cancer-induced bone metastases and muscle weakness [PDF]
, 2019 Breast cancer bone metastases often cause a debilitating non-curable condition with osteolytic lesions, muscle weakness and a high mortality. Current treatment comprises chemotherapy, irradiation, surgery and anti-resorptive drugs that restrict but do ...
Brandt, Diana +5 more
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BMC Geriatrics, 2022 Background Handgrip strength (HGS) is a simple, quick, inexpensive, and highly reliable method for the assessment of muscle strength in clinical practice and epidemiological studies.
Bruno de Souza Moreira +6 more
doaj +1 more source
Acute Nontraumatic Muscle Weakness
Journal of Neuroanaesthesiology and Critical Care, 2019 Acute nontraumatic weakness (ANTW) is defined as acute onset of weakness in any part of the body. The weakness occurs due to interruption at any point along the motor pathway.
Kiran Jangra +2 more
doaj +1 more source
Late-onset thymidine kinase 2 deficiency: a review of 18 cases [PDF]
, 2019 BACKGROUND: TK2 gene encodes for mitochondrial thymidine kinase, which phosphorylates the pyrimidine nucleosides thymidine and deoxycytidine. Recessive mutations in the TK2 gene are responsible for the 'myopathic form' of the mitochondrial depletion ...
Caballero Eraso, Candelaria +9 more
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The association between muscle strength and activity limitations in patients with the hypermobility type of Ehlers–Danlos syndrome : the impact of proprioception [PDF]
, 2016 Purpose: The patients diagnosed with Ehlers-Danlos Syndrome Hypermobility Type (EDS-HT) are characterized by pain, proprioceptive inacuity, muscle weakness, potentially leading to activity limitations.
Calders, Patrick +8 more
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How human gait responds to muscle impairment in total knee arthroplasty patients: Muscular compensations and articular perturbations [PDF]
, 2016 Post-surgical muscle weakness is prevalent among patients who undergo total knee arthroplasty (TKA). We conducted a probabilistic multi-body dynamics (MBD) to determine whether and to what extent habitual gait patterns of TKA patients may accommodate ...
Ardestani, MM, Moazen, M
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A chronic low dosage of taurine induces muscle weakness in castrated-aged mice
Translational Medicine of Aging, 2021 Taurine is an abundant metabolite associated with regulation of cell volume. Several signaling pathways are stimulated at a micromolar concentrations of taurine. However, most of the experimental studies employ this compound at a very high concentration (
Noelia G. Barragán-Ceballos +8 more
doaj +1 more source
Mechanisms of Muscle Weakness Associated with Bone Metastases [PDF]
, 2017 Cancer-associated muscle dysfunction represents a deadly clinical problem, with ca. 80% mortality together with an increased toxicity from cancer treatment.. The normal bone remodeling might be disrupted by tumor cells that metastasize to bone in certain
Guise, Theresa A. +3 more
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Increased amino acid turnover and myofibrillar protein breakdown in advanced cancer are associated with muscle weakness and impaired physical function [PDF]
, 2018 Muscle wasting in cancer negatively affects physical function and quality of life. This study investigates amino acid metabolism and the association with muscle mass and function in patients with cancer.In 16 patients with advanced cancer undergoing ...
Deutz, Nicolaas E P +3 more
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Sarcoidosis presenting as granulomatous myositis in a 16-year-old adolescent [PDF]
, 2016 BACKGROUND: Sarcoidosis is a multi-system disease characterized by the presence of non-caseating epithelioid granulomas in affected tissues, including skeletal muscle.
Eutsler, Eric Eutsler +4 more
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