Results 81 to 90 of about 1,024,120 (317)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Carbamazepine-responsive paroxysmal nausea and vomiting in a patient with meningeal carcinomatosis [PDF]

, 2006
In neurology, paroxysmal syndromes are well-known, eg, as manifestations of multiple sclerosis. We report a patient with meningeal carcinomatosis, who presented with therapyrefractory nausea and vomiting.
Borasio, Gian Domenico
core   +1 more source

Cutaneous manifestations of bartonellosis

Anais Brasileiros de Dermatologia, 2019
Bartonellosis are diseases caused by any kind of Bartonella species. The infection manifests as asymptomatic bacteremia to potentially fatal disorders. Many species are pathogenic to humans, but three are responsible for most clinical symptoms: Bartonella bacilliformis, Bartonella quintana, and Bartonella henselae.
Karina de Almeida Lins, Marina Rovani Drummond, Paulo Eduardo Neves Ferreira Velho   +2 more
openaire   +5 more sources

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Oral Manifestations of HIV Infection in Children and Adults Receiving Highly Active Anti-Retroviral Therapy [HAART] in Dar es Salaam,Tanzania [PDF]

, 2006
The aim of the study was to compare the prevalence and types of HIV-related oral lesions between children and adult Tanzanian patients on HAART with those not on HAART and to relate the occurrence of the lesions with anti-HIV drug regimen, clinical stage
Simon, Elison NM, Matee, M.I.N, Mikx, F.H., Simon, E.N., Verweij Paul E, JAM van der Ven, André, Mugusi, F, Paul E Verweij, Mugusi Ferdinand, Simon Elison NM, Verweij, P.E, Moshi, M.J., Verweij, P.E., Moshi Mainen J, Simon, E.N.M, Simon, Elison N M, André JAM van der Ven, Matee, Mecky I N, Moshi, M.J, Kikwilu, Emil, Mecky IN Matee, Mikx, Frans H M, Matee, M.I., Omar JM Hamza, Hamza, Omar JM, Moshi, Mainen J, Matee, Mecky IN, Van der Ven, A.J., Kikwilu Emil, Kikwilu, E., Mugusi, F., van der Ven, André J A M, Mainen J Moshi, Frans HM Mikx, Verweij, Paul E, Mikx, F.H.M, Ferdinand Mugusi, Mugusi, Ferdinand, Hamza, Omar J M, Emil Kikwilu, van der Ven André JAM, Hamza, OJ., Hamza, O.J.M, Elison NM Simon, Mikx Frans HM, Matee Mecky IN, Hamza Omar JM, Mikx, Frans HM   +47 more
core   +1 more source

Manifestations of Malnutrition [PDF]

BMJ, 1947
B, MAYNE, L, MacFARLANE
openaire   +5 more sources

CUTANEOUS MANIFESTATIONS IN BRUCELLOSIS

Indian Journal of Dermatology, 2011
Brucellosis is a common worldwide zoonotic disease. Cutaneous manifestations are not specific and affect 1-14% of patients with brucellosis. Here, we describe 49-year-old female with fever and a diffuse maculopapular rash due to Brucella melitensis infection.
Zeynep Karaali, Birol Baysal, Sule Poturoglu, Mehmet Kendir   +3 more
openaire   +3 more sources

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source