Results 91 to 100 of about 730,787 (266)

Identifying Constant Curvature Manifolds, Einstein Manifolds, and Ricci Parallel Manifolds [PDF]

The Journal of Geometric Analysis, 2018
We establish variational formulas for Ricci upper and lower bounds, as well as a derivative formula for the Ricci curvature. As applications, constant curvature manifolds, Einstein manifolds and Ricci parallel manifolds are identified, respectively, with different integral-differential formulas and semigroup inequalities.
openaire   +4 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

On kenmotsu manifold

Communications, Faculty Of Science, University of Ankara Series A1Mathematics and Statistics, 2005
Summary: The object of this paper is to study a type of Kenmotsu manifold called Kenmotsu \((GR)_n\)-manifold and Kenmotsu \(G(PRS)_n\) manifold \((n>2)\). The \(W_4\)-curvature tensor on Kenmotsu manifolds is also studied.
Prasad, B., Verma, R. K.
openaire   +3 more sources

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Detecting phase transitions in collective behavior using manifold's curvature

Mathematical Biosciences and Engineering, 2017
If a given behavior of a multi-agent system restricts the phase variable to an invariant manifold, then we define a phase transition as a change of physical characteristics such as speed, coordination, and structure.
Kelum Gajamannage, Erik M. Bollt
doaj   +1 more source

Exploded manifolds

Advances in Mathematics, 2012
v4 Post-publication(!) correction to Definition 3.1 of an abstract exploded space. See footnotes on pages 14 and 22.
openaire   +4 more sources

3-Manifolds everywhere

Journal de Mathématiques Pures et Appliquées, 2017
A random group contains many subgroups which are isomorphic to the fundamental group of a compact hyperbolic 3-manifold with totally geodesic boundary. These subgroups can be taken to be quasi-isometrically embedded. This is true both in the few relators model, and the density model of random groups (at any density less than a half).
Calegari, D, Wilton, HJR
openaire   +3 more sources

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source