Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Hybrid Analytical and Simulation-Based Approach for Workspace Verification of a Pneumatic Upper Limb Exoskeleton. [PDF]
Sensors (Basel)Mayorov N +3 more
europepmc +1 more source
Reliability Analysis of Kinematic Accuracy of a Three Degree-of-Freedom Parallel Manipulator
, 2010 The reliability of kinematic trajectory of manipulators describes the ability that manipulators keep kinematic accurate. It is an important parameter to evaluate the performance of manipulators. The kinematic accuracy of manipulators can be improved when
Ying Wu +5 more
core
Small RNA pathways in mammalian oocytes
FEBS Open Bio, EarlyView.Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley +1 more source
Autonomous trajectory planning for an underwater electric manipulator based on force sensing
, 2016 Efficiency and accuracy could be improved by greater degree of automation in underwater tasks operating. However, there is a prerequisite that the manipulator should have a desired end-effector trajectory and suitable force applied to the environment to ...
Fan YL(范云龙) +4 more
core
Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA
FEBS Open Bio, EarlyView.PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro +1 more
wiley +1 more source
Manipulator-Free Versus Manipulator-Assisted Total Laparoscopic Hysterectomy: Are Outcomes Comparable in Experienced Hands? [PDF]
Med Sci MonitErdem B, Erciyestepe SG.
europepmc +1 more source
FEBS Open Bio, EarlyView.The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley +1 more source
To manipulate or not to manipulate, that is the question
The Journal of the American Osteopathic Association, 1991 openaire +3 more sources
Policy-Guided Model Predictive Path Integral for Safe Manipulator Trajectory Planning. [PDF]
Sensors (Basel)Liang L, Wu C, Wang X.
europepmc +1 more source