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The lectin pathway of complement activation is a critical component of the innate immune response to pneumococcal infection. [PDF]
PLoS Pathogens, 2012 The complement system plays a key role in host defense against pneumococcal infection. Three different pathways, the classical, alternative and lectin pathways, mediate complement activation.Youssif M Ali, Nicholas J Lynch, Kashif S Haleem, Teizo Fujita, Yuichi Endo, Soren Hansen, Uffe Holmskov, Kazue Takahashi, Gregory L Stahl, Thomas Dudler, Umakhanth V Girija, Russell Wallis, Aras Kadioglu, Cordula M Stover, Peter W Andrew, Wilhelm J Schwaeble +15 moredoaj +5 more sourcesRecognition of Staphylococcus aureus by the pattern recognition molecules langerin, mannan-binding lectin, and surfactant protein D: the influence of capsular polysaccharides and wall teichoic acid [PDF]
Frontiers in ImmunologyThe innate immune system plays a critical role in the rapid recognition and elimination of pathogens through pattern recognition receptors (PRRs). Among these PRRs are the C-type lectins (CTLs) langerin, mannan-binding lectin (MBL), and surfactant ...Kirstine Mejlstrup Hymøller, Kirstine Mejlstrup Hymøller, Stig Hill Christiansen, Stig Hill Christiansen, Anders Grønnegaard Schlosser, Uffe B. Skov Sørensen, Jean C. Lee, Steffen Thiel, Steffen Thiel +8 moredoaj +2 more sourcesProgressive IgA Nephropathy Is Associated With Low Circulating Mannan-Binding Lectin–Associated Serine Protease-3 (MASP-3) and Increased Glomerular Factor H–Related Protein-5 (FHR5) Deposition
Kidney International Reports, 2018 IgA nephropathy (IgAN) is characterized by glomerular deposition of galactose-deficient IgA1 and complement proteins and leads to renal impairment. Complement deposition through the alternative and lectin activation pathways is associated with renal ...Nicholas R. Medjeral-Thomas, Anne Troldborg, Nicholas Constantinou, Hannah J. Lomax-Browne, Annette G. Hansen, Michelle Willicombe, Charles D. Pusey, H. Terence Cook, Steffen Thiel, Matthew C. Pickering +9 moredoaj +3 more sourcesLectin-Dependent Enhancement of Ebola Virus Infection via Soluble and Transmembrane C-type Lectin Receptors [PDF]
, 2013 Mannose-binding lectin (MBL) is a key soluble effector of the innate immune system that recognizes pathogen-specific surface glycans. Surprisingly, low-producing MBL genetic variants that may predispose children and immunocompromised individuals to ...A Hurtado-Lorenzo, A Nanbo, A Puig-Kroger, A Sanchez, A Takada, A Takada, A Takada, A Yonezawa, AB Boldt, AD Hyatt, AG Bowie, AL Brass, Alan B. Ezekowitz, AM Kerrigan, Amel Omari, Anna Sokolovska, AS Kondratowicz, AS Powlesland, Ashish Sarraju, B Ghebrehiwet, BJ Shiell, BM Gunn, Bradley S. Schneider, Bruce A. Mungall, BT Rouse, CA Blanchong, CA Zampieri, Calli Lear, CD Collard, CF Spiropoulou, CL Hood, CL Hunt, Corinne Scully, CP Alvarez, D Dube, D Dube, Damon P. Eisen, Darrell N. Kotton, DJ Vigerust, DL Jack, DM Tobin, E Matei, E McGreal, E Mehlhop, Emmett V. Schmidt, G Catano, Gene G. Olinger, Gregory L. Stahl, Gregory T. Spear, H Feldmann, H Feldmann, H Zhang, HO Madsen, I-Chueh Huang, Ian C. Michelow, IC Michelow, IC Michelow, IJ de Messias-Reason, J Mercer, J Mercer, J Moffat, J Seyfarth, J Seyfarth, JE Lee, JH Kuhn, JL Casanova, JM Rojek, JR Francica, JS Towner, JT Denholm, K Chandran, K Li, K Quinn, K Saxena, K Schornberg, K Takahashi, Kazue Takahashi, L Kainulainen, L Xu, L. Michael Yantosca, LD Powell, LG Barrientos, Li Chen, Lynda Stuart, M Cote, M Dong, M Shimojima, M Super, M. Reza Zariffard, Marshall Karpel, Matthew Brudner, MC Pickering, MF Medina, MF Saeed, Michael Farzan, MS Maginnis, MT Ling, N Bayer, NJ Klein, O Dolnik, O Reynard, P Garred, P Phanuphak, R Pagh, R Steffensen, RA Ezekowitz, RA Hawkes, RL Kaletsky, RR Nepomuceno, S Bhattacharyya, S Thiel, S Thiel, S Thiel, SB Halstead, SJ Gardai, SL Hanna, T Bernig, T Vorup-Jensen, WA Williamson, WB Oswald, WJ Schwaeble, WK Ip, WK Ip, X Ji, Y Yang, YL Wu +125 morecore +21 more sourcesComplement lectin pathway activation is associated with COVID-19 disease severity, independent of MBL2 genotype subgroups
Frontiers in Immunology, 2023 IntroductionWhile complement is a contributor to disease severity in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, all three complement pathways might be activated by the virus.Lisa Hurler, Ágnes Szilágyi, Federica Mescia, Federica Mescia, Laura Bergamaschi, Laura Bergamaschi, Blanka Mező, Blanka Mező, György Sinkovits, Marienn Réti, Veronika Müller, Zsolt Iványi, János Gál, László Gopcsa, Péter Reményi, Beáta Szathmáry, Botond Lakatos, János Szlávik, Ilona Bobek, Zita Z. Prohászka, Zsolt Förhécz, Dorottya Csuka, Erika Kajdácsi, László Cervenak, Petra Kiszel, Tamás Masszi, István Vályi-Nagy, Reinhard Würzner, Cambridge Institute of Therapeutic Immunology and Infectious Disease-National Institute of Health Research (CITIID-NIHR) COVID BioResource Collaboration, Paul A. Lyons, Paul A. Lyons, Erik J. M. Toonen, Zoltán Prohászka, Zoltán Prohászka, Stephen Baker, John R. Bradley, Patrick F. Chinnery, Daniel J. Cooper, Gordon Dougan, Ian G. Goodfellow, Ravindra K. Gupta, Nathalie Kingston, Paul J. Lehner, Paul A. Lyons, Nicholas J. Matheson, Caroline Saunders, Kenneth G. C. Smith, Charlotte Summers, James Thaventhiran, M. Estee Torok, Mark R. Toshner, Michael P. Weekes, Gisele Alvio, Sharon Baker, Areti Bermperi, Karen Brookes, Ashlea Bucke, Jo Calder, Laura Canna, Cherry Crucusio, Isabel Cruz, Rnalie de Jesus, Katie Dempsey, Giovanni Di Stephano, Jason Domingo, Anne Elmer, Julie Harris, Sarah Hewitt, Heather Jones, Sherly Jose, Jane Kennet, Yvonne King, Jenny Kourampa, Emily Li, Caroline McMahon, Anne Meadows, Vivien Mendoza, Criona O’Brien, Charmain Ocaya, Ciro Pascuale, Marlyn Perales, Jane Price, Rebecca Rastall, Carla Ribeiro, Jane Rowlands, Valentina Ruffolo, Hugo Tordesillas, Phoebe Vargas, Bensi Vergese, Laura Watson, Jieniean Worsley, Julie-Ann Zerrudo, Laura Bergamaschi, Ariana Betancourt, Georgie Bower, Ben Bullman, Chiara Cossetti, Aloka De Sa, Benjamin J. Dunore, Maddie Epping, Stuart Fawke, Stefan Gräf, Richard Grenfell, Andrew Hinch, Josh Hodgson, Christopher Huang, Oisin Huhn, Kelvin Hunter, Isobel Jarvis, Emma Jones, Maša Josipović, Ekaterina Legchenko, Daniel Lewis, Joe Marsden, Jennifer Martin, Federica Mescia, Francesca Nice, Ciara O’Donnell, Ommar Omarjee, Marianne Perera, Linda Pointon, Nicole Pond, Nathan Richoz, Nika Romashova, Natalia Savoinykh, Rahul Sharma, Joy Shih, Mateusz Strezlecki, Rachel Sutcliffe, Tobias Tilly, Zhen Tong, Carmen Treacy, Lori Turner, Jennifer Wood, Marta Wylot, John Allison, Heather Biggs, Helen Butcher, Daniela Caputo, Debbie Clapham-Riley, Eleanor Dewhurst, Christian Fernandez, Anita Furlong, Barbara Graves, Jennifer Gray, Tasmin Ivers, Emma Le Gresley, Rachel Linger, Mary Kasanicki, Sarah Meloy, Francesca Muldoon, Nigel Ovington, Sofia Papadia, Christopher J. Penkett, Isabel Phelan, Venkatesh Ranganath, Jennifer Sambrook, Katherine Schon, Hannah Stark, Kathleen E. Stirrups, Paul Townsend, Julie von Ziegenweidt, Jennifer Webster, Ali Asaripour, Lucy Mwaura, Caroline Patterson, Gary Polwarth, Katherine Bunclark, Michael Mackay, Alice Michael, Sabrina Rossi, Mayurun Selvan, Sarah Spencer, Cissy Yong, Petra Polgarova +174 moredoaj +1 more sourceComplement lectin pathway components MBL and MASP-1 promote haemostasis upon vessel injury in a microvascular bleeding model
Frontiers in Immunology, 2022 BackgroundComplement lectin pathway components, in particular mannan-binding lectin (MBL) and MBL-associated serine proteases (MASPs) have been shown to interact with coagulation factors and contribute to clot formation.Murielle Golomingi, Jessie Kohler, Lorenz Jenny, Elaissa T. Hardy, József Dobó, Péter Gál, Gábor Pál, Bence Kiss, Wilbur A. Lam, Verena Schroeder +9 moredoaj +1 more source
