Results 91 to 100 of about 4,456 (216)

CL‐11 circulates in serum as functionally distinct isoforms

The FASEB Journal, Volume 38, Issue 5, 15 March 2024.
CL‐11 is a pattern recognition molecule that interacts with CL‐10 and the MASPs to activate the lectin pathway of the complement system. CL‐11 is found circulating in blood as isoforms A (full length) and D (with a shorter collagen‐like region caused by the lack of exon 4).
Adrian Sutta, Nelia Nina Leemans, Michael Ploug, Anne Rosbjerg, Christian del Agua Villa, Laura Pérez‐Alós, Leon Cyranka, Adam S. Vincek, Tomás de Garay, Keith Rivera, Rafael Bayarri‐Olmos   +10 more
wiley   +1 more source

Complement in patients receiving maintenance hemodialysis: functional screening and quantitative analysis [PDF]

, 2010
Background The complement system is vital for innate immunity and is implicated in the pathogenesis of inflammatory diseases and the mechanism of host defense. Complement deficiencies occasionally cause life-threatening diseases.
Hiroyuki Inoshita, Isao Ohsawa, Gaku Kusaba, Masaya Ishii, Kisara Onda, Satoshi Horikoshi, Hiroyuki Ohi, Yasuhiko Tomino   +7 more
core   +2 more sources

Advances in the treatment of IgA nephropathy with biological agents

Chronic Diseases and Translational Medicine, Volume 10, Issue 1, Page 1-11, March 2024.
Pathogenesis of immunoglobulin A (IgA) nephropathy: four‐hit mechanism. Gld‐IgA1, galactose‐deficient IgA1. Hit 1: production of Gld‐IgA1 by a subpopulation of IgA1‐secreting cells. Hit 2: circulating antibodies directed against Gld‐IgA1. Hit 3: formation of pathogenic Gld‐IgA1‐containing immune complexes.
Yongze Zhuang, Hailing Lu, Junxia Li
wiley   +1 more source

Differential Role of the Lectin Pathway of Complement Activation in Susceptibility to Neonatal Sepsis [PDF]

, 2017
Background. The incidence of bacterial sepsis during the neonatal period is high. Mannan-binding lectin (MBL), L-ficolin, and H-ficolin recognize microorganisms and activate the complement system viaMBL-associated serine proteases (MASPs).
Boillat, Colette, Christoph, Aebi, Jensenius, Jens C., Mattmann, Maika, Nelle, Mathias, Otth, Margrith, Schlapbach, Luregn J., Thiel, Steffen, Wagner, Bendicht   +8 more
core  

Molecular basis of sugar recognition by collectin-K1 and the effects of mutations associated with 3MC syndrome [PDF]

, 2015
Background Collectin-K1 (CL-K1, or CL-11) is a multifunctional Ca2+-dependent lectin with roles in innate immunity, apoptosis and embryogenesis. It binds to carbohydrates on pathogens to activate the lectin pathway of complement and together with its ...
A Katrine, Wallis, Alexandre R, Gingras, Christopher M, Furze, Daniel A, Mitchell, Jamie E, Marshall, Mohammed, El-Mezgueldi, Ohtani, Katsuki, Peter CE, Moody, Russell, Wallis, Umakhanth, Venkatraman Girija, Wakamiya, Nobutaka, Wilhelm J, Schwaeble, Yoshizaki, Takayuki, オオタニ, カツキ, ヨシザキ, タカユキ, ワカミヤ, ノブタカ, 吉崎, 隆之, 大谷, 克城, 若宮, 伸隆   +18 more
core   +6 more sources

High‐Mannose Oligosaccharide Hemimimetics that Recapitulate the Conformation and Binding Mode to Concanavalin A, DC‐SIGN and Langerin

Chemistry – A European Journal, Volume 30, Issue 2, January 8, 2024.
The “carbohydrate chemical mimicry” of sp2‐iminosugars enables the synthesis of high‐mannose‐type oligosaccharide analogs whose solution and lectin bound conformations match those of the natural partners. Upon multivalent presentation, enhanced affinities towards ConA, DC‐SIGN and langerin are achieved, with distinct selectivity profiles. Abstract The “
Irene Herrera‐González, Manuel González‐Cuesta, Michel Thépaut, Eugénie Laigre, David Goyard, Javier Rojo, José M. García Fernández, Franck Fieschi, Olivier Renaudet, Pedro M. Nieto, Carmen Ortiz Mellet   +10 more
wiley   +1 more source

Mannan-Binding Lectin Suppresses Peptidoglycan-Induced TLR2 Activation and Inflammatory Responses

Mediators of Inflammation, 2019
Peptidoglycan (PGN), as the major components of the bacterial cell wall, is known to cause excessive proinflammatory cytokine production. Toll-like receptor 2 (TLR2) is abundantly expressed on immune cells and has been shown to be involved in PGN-induced
Fanping Wang, Yanhua Li, Can Yang, Yonghui Mu, Yan Wang, Wei Zhang, Yonghui Yang, Chen Chen, Shijun Song, Zhifa Shen, Wenjun Wang, Junpeng Li, Jingjing Zhai, Kang Guo, Ruili Sun, Lili Yu, Mingyong Wang   +16 more
doaj   +1 more source

Herpes simplex encephalitis in adult patients with MASP-2 deficiency.

PLoS Pathogens, 2019
We report here two cases of Herpes simplex virus encephalitis (HSE) in adult patients with very rare, previously uncharacterized, non synonymous heterozygous G634R and R203W substitution in mannan-binding lectin serine protease 2 (MASP2), a gene encoding
Stéphanie Bibert, Jocelyne Piret, Mathieu Quinodoz, Emilie Collinet, Vincent Zoete, Olivier Michielin, Rafik Menasria, Pascal Meylan, Titus Bihl, Véronique Erard, Florence Fellmann, Carlo Rivolta, Guy Boivin, Pierre-Yves Bochud   +13 more
doaj   +1 more source

Mannan-Binding Lectin Attenuates Inflammatory Arthritis Through the Suppression of Osteoclastogenesis

Frontiers in Immunology, 2019
Mannan-binding lectin (MBL) is a vital element in the host innate immune system, which is primarily produced by the liver and secreted into the circulation. Low serum level of MBL is reported to be associated with an increased risk of arthritis. However,
Lijun Dong, Jun Wu, Kai Chen, Jingwen Xie, Youyi Wang, Youyi Wang, Dantong Li, Yunzhi Liu, Aiping Yin, Yue Zhao, Yunpeng Han, Jia Zhou, Liyun Zhang, Zhengliang Chen, Zhengliang Chen, Daming Zuo, Daming Zuo, Daming Zuo, Daming Zuo   +18 more
doaj   +1 more source

Isolation and expression of a novel MBL-like collectin cDNA enhanced by LPS injection in the body wall of the ascidian Ciona intestinalis [PDF]

, 2009
Collectins are a family of calcium-dependent lectins that are characterized by their collagen-like domains. Considerable interest has been focused on this class of proteins because of their ability to interact with components of the complement system ...
Bonura, A., Colombo, P., Longo, V., Parrinello, N., Salerno, G., Vizzini, A.   +5 more
core   +1 more source