Results 171 to 180 of about 4,456 (216)

Location of MBL-Associated Serine Proteases Binding Motifs on Human Mannan-Binding Lectin (MBL)

Protein & Peptide Letters, 2010
The lectin pathway provides an antibody independent route of complement activation. Mannan-binding lectin (MBL) can form compound with MBL-associated serine proteases (MASPs) through its collagen-like region (CLR) to initiate complement fixation. In this study, we designed and synthesized a range of peptides according to the sequence of CLR in human ...
Daming, Zuo, Xuemin, Cai, Na, Zhao, Liyun, Zhang, Zhengliang, Chen   +4 more
openaire   +2 more sources

Mannan-binding lectin (MBL) production from human plasma

Biochemical Society Transactions, 2003
Individuals with low levels of mannan-binding lectin (MBL) appear to be susceptible to infectious diseases. This suggests that substitution therapy with MBL might be a beneficial treatment of patients with MBL deficiency. A production process for an MBL product has been developed from a fraction II+III precipitate obtained by ethanol fractionation of ...
openaire   +2 more sources

Serum mannan‐binding lectin (MBL) in patients with infection: clinical and laboratory correlates

APMIS, 1997
In this study, we determined the serum levels of mannan‐binding lectin (MBL) in patients with suspected or documented infection to characterize the possible role of MBL in the susceptibility to infection. We also investigated the kinetics of MBL during the infection and correlated the concentrations of MBL with those of acute‐phase reactants C‐reactive
J, Aittoniemi, E, Rintala, A, Miettinen, E, Soppi   +3 more
openaire   +2 more sources

Circulating levels of mannan-binding lectin (MBL) and MBL-associated serine protease 2 in endemic pemphigus foliaceus

Clinical and Experimental Dermatology, 2008
Endemic pemphigus foliaceus (EPF) is an autoimmune disease, which occurs in Brazil and other regions of South America. Mannose-binding lectin (MBL) and MBL-associated serine protease (MASP-2) play a key role in innate immunity, and its deficiency has been related to increased susceptibility to infection and autoimmune diseases.
Messias-Reason, I, Bosco, D G, Nisihara, R M, Jakobsen, L H, Petzl-Erler, M L, Jensenius, Jens Christian   +5 more
openaire   +3 more sources

Consensus statement on the future of mannan-binding lectin (MBL)-replacement therapy

Biochemical Society Transactions, 2003
Prepared by David C. Kilpatrick on behalf of the speakers and delegates. There follows a consensus statement on the future of mannan-binding lectin replacement therapy to ‘wrap up’ this series of articles.
openaire   +2 more sources

Analysis of low molecular weight intracellular associations of a human mannan binding lectin (MBL)

Molecular Immunology, 2004
Human mannan binding lectin (MBL) is a member of the collectins, a group of proteins that contain a dual structure with a lectin and a collagenous moieties. The collectins are considered as major actors of innate immunity. We report the presence of low molecular weight intracellular MBL forms in human hepatocytic cell lysates, with binding capacities ...
Dumestre-Perard, C., Ponard, D., Colomb, M. G.   +2 more
openaire   +2 more sources

Mannan-binding lectin (MBL)-mediated opsonization is enhanced by the alternative pathway amplification loop

Molecular Immunology, 2006
The complement system is a humoral effector in the innate immune system. Three activation pathways exist in the complement system, known as the classical pathway, the lectin pathway and the alternative pathway. Dysfunction of lectin pathway activation is caused by MBL deficiency.
Brouwer, Nannette, Dolman, Koert M., van Zwieten, Rob, Nieuwenhuys, Ed, Hart, Margreet, Aarden, Lucien A., Roos, Dirk, Kuijpers, Taco W.   +7 more
openaire   +3 more sources

[Mannan-binding lectin (MBL) in duodenal ulcer and gastritis].

Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 2009
H. pylori is considered to be a major etiological agent of chronic gastritis. Mannan-binding lectin (MBL) is one of the key factors of the innate immunity. It belongs to collectins binding to saccharides on the surface of a variety of pathogenic microorganisms, H. pylori including.
Leokadia, Bak-Romaniszyn, Anna, Swierzko, Janusz, Szemraj, Agnieszka, Szala, Maciej, Cedzyński, Ewa, Małecka-Panas, Krzysztof, Zeman   +6 more
openaire   +1 more source

[Mannan-binding lectin and MBL-associated serine protease-2].

Ugeskrift for laeger, 2008
In Denmark approximately 3,600 patients are diagnosed with colorectal cancer (CRC) every year. 75-80% of patients may undergo intended curative resection, but the disease recurs in about 40% within five years and the prognosis is poor. Hence, there is a need for biological markers that could be used for detection, evaluation of prognosis, therapy ...
Jorgensen, J., Ytting, H., Steffensen, R.M., Nielsen, Hans Jørgen   +3 more
openaire   +1 more source

Fibrosis severity and mannan-binding lectin (MBL)/MBL-associated serine protease 1 (MASP-1) complex in HCV-infected patients

Arab Journal of Gastroenterology, 2011
Mannan-binding lectin (MBL) is a collectin synthesised in the liver and secreted into the bloodstream. It binds micro-organisms via interactions with glycans on the target surface. Bound MBL subsequently activates MBL-associated serine protease proenzymes (MASPs).
Sherif A, El Saadany, Dina H, Ziada, Wael, Farrag, Sahar, Hazaa   +3 more
openaire   +2 more sources